Version history

{
  "kind": "infographic",
  "prompt": "4. Translaminar excitatory loops in mouse — L4→L2/3→L5→L6→L4 within the column; asymmetry of forward and backward intracortical projections figure 2",
  "provider": "other",
  "raw_fields": {
    "axes": {
      "x": "presynaptic-postsynaptic layer pair / cell-pair tuning correlation",
      "y": "unitary EPSP amplitude (mV) or efficacy"
    },
    "datasets": [
      {
        "doi": "10.1016/j.neuron.2008.12.020",
        "method": "paired recording across 6 layers",
        "system": "mouse C2 barrel column",
        "value_summary": "Layer-specific EPSP amplitudes with rare large-amplitude E→E connections in all layers.",
        "claim_source_sentence": "In all layers we found rare large-amplitude synaptic connections, which are likely to contribute strongly to reliable information processing."
      },
      {
        "doi": "10.1038/nature14182",
        "method": "paired recording + 2P functional imaging",
        "system": "mouse V1 L2/3",
        "value_summary": "L2/3→L2/3 EPSP amplitudes span >2 orders of magnitude; few strong connections between maximally correlated neurons.",
        "claim_source_sentence": "Excitatory connection amplitudes between pairs of cortical neurons vary over two orders of magnitude, comprising only very few strong connections among many weaker ones."
      },
      {
        "doi": "10.1093/cercor/bhx094",
        "method": "paired recording",
        "system": "mouse C2 barrel column",
        "value_summary": "Layer-dependent short-term plasticity directions: depression dominant at many layer pairs; L2 presynaptic gives facilitation at 10–30 ms ISI.",
        "claim_source_sentence": "We find layer-dependent short-term plasticity, with depression being dominant at many synaptic connections."
      },
      {
        "doi": "10.1126/science.abj5861",
        "method": "Allen Institute synaptic physiology platform — paired recordings",
        "system": "mouse and human cortex multi-patch dataset (mouse portion in scope)",
        "value_summary": "Strength and variability are the two main axes of E synapse heterogeneity; subclasses divide along the variability axis.",
        "claim_source_sentence": "The two main axes of heterogeneity are strength and variability. Cell subclasses divide along the variability axis, whereas the strength axis accounts for substantial heterogeneity within the subclass."
      },
      {
        "doi": "10.1523/JNEUROSCI.0836-14.2015",
        "method": "paired patch + retrograde labeling",
        "system": "mouse auditory cortex",
        "value_summary": "L2/3→L5B unitary EPSC amplitude/latency/rise/decay are identical for corticocollicular vs corticocallosal targets but short-term plasticity differs (no depression vs substantial depression).",
        "claim_source_sentence": "In paired recordings between single L2/3 and labeled L5B neurons, the probabilities of connection, amplitude, latency, rise time, and decay time constant of the unitary EPSC were not different for L2/3→corticocollicular and L2/3→corticocallosal connections."
      }
    ],
    "audit_issues": [
      {
        "dimension": "metric_definition",
        "description": "Distributions are reported in different quantities (EPSP amplitude, short-term-plasticity ratio, EPSC amplitude/latency/rise/decay; 'strength + variability axes'). No single y-axis encompasses them.",
        "entries_affected": [
          "10.1016/j.neuron.2008.12.020",
          "10.1038/nature14182",
          "10.1093/cercor/bhx094",
          "10.1126/science.abj5861",
          "10.1523/JNEUROSCI.0836-14.2015"
        ]
      },
      {
        "dimension": "scope_region",
        "description": "S1 barrel column (Lefort, Lavzin), V1 L2/3 (Cossell), and auditory cortex L2/3→L5B (Williamson). Mixed sensory cortices.",
        "entries_affected": [
          "10.1016/j.neuron.2008.12.020",
          "10.1038/nature14182",
          "10.1093/cercor/bhx094",
          "10.1523/JNEUROSCI.0836-14.2015"
        ]
      },
      {
        "dimension": "scope_population",
        "description": "Layer-pair scopes differ: full 6-layer pairs, L2/3→L2/3, L2/3→L5B target-specific. Distribution shapes are not commensurable when pooled.",
        "entries_affected": [
          "10.1016/j.neuron.2008.12.020",
          "10.1038/nature14182",
          "10.1523/JNEUROSCI.0836-14.2015"
        ]
      }
    ],
    "audit_verdict": "CAVEAT",
    "figure_concept": "Translaminar E→E unitary EPSP amplitude / synaptic strength distributions in mouse cortex",
    "interpretation_note": "Numeric EPSP amplitudes are recorded as paper-specific values; the figure compares unitary strength distributions, log-normal shape (Cossell 2015), translaminar L2/3→L5B sub-target equivalence (Joshi 2015), short-term-plasticity direction (Frandolig 2017), and the Allen synaptic physiology axes (Campagnola 2022).",
    "mandatory_caption_caveats": [
      "Distributions are quantified in different ways (amplitude, short-term-plasticity index, multi-axis decomposition); rows are not directly stackable on a single amplitude axis.",
      "Layer-pair scopes differ across rows (whole 6-layer matrix, L2/3→L2/3 only, L2/3→L5B target-specific)."
    ]
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [],
  "section_title": "4. Translaminar excitatory loops in mouse — L4→L2/3→L5→L6→L4 within the column; asymmetry of forward and backward intracortical projections",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}