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- Live5/17/2026, 4:35:28 PM
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{ "kind": "infographic", "prompt": "Convergent evidence across paired recordings, functional EM of L2/3, and millimetre-scale connectomics that excitatory-to-excitatory wiring in mouse V1 is biased by tuning similarity — most strongly for the few large-amplitude connections — and that the rule extends across layers and visual areas.", "provider": "other", "raw_fields": { "papers": [ { "n": 0, "doi": "10.1038/nature09880", "value": "~2× higher for same vs orthogonal orientation", "method": "paired recordings preceded by in vivo two-photon Ca imaging", "metric": "connection probability — same vs orthogonal orientation", "n_analyzed": "not reported in abstract", "ci_or_error": "qualitative ratio", "text_access": "abstract_only", "n_definition": "V1 L2/3 pyramidal pairs tested in vitro after in vivo characterization", "scope_region": "V1, local L2/3 microcircuit", "study_system": "mouse V1 L2/3; in vivo Ca imaging + in vitro paired recordings", "taxonomic_level": "cell-class", "scope_population": "L2/3 pyramidal neurons", "value_source_sentence": "Neurons with the same preference for oriented stimuli connected at twice the rate of neurons with orthogonal orientation preferences.", "experimental_conditions": "adult mice with normal visual experience" }, { "n": 0, "doi": "10.1038/nature14182", "value": "~2 orders of magnitude span; strongest connections among most-correlated pairs", "method": "paired recordings + in vivo Ca imaging", "metric": "distribution of connection strength vs signal correlation", "n_analyzed": "not in abstract", "ci_or_error": "distribution span", "text_access": "abstract_only", "n_definition": "L2/3 pyramidal pairs with paired EPSPs", "scope_region": "V1, local L2/3 microcircuit", "study_system": "mouse V1 L2/3; paired patch + in vivo Ca imaging", "taxonomic_level": "cell-class", "scope_population": "L2/3 pyramidal neurons", "value_source_sentence": "Excitatory connection amplitudes between pairs of cortical neurons vary over two orders of magnitude, comprising only very few strong connections among many weaker ones.", "experimental_conditions": "adult mice" }, { "n": 0, "doi": "10.1038/nature17192", "value": "Same-orientation pairs preferentially synapsing despite uniform axon–dendrite proximity", "method": "two-photon Ca imaging + serial-section EM", "metric": "orientation-similarity selectivity of synapse formation (EM)", "n_analyzed": "not reported in abstract", "ci_or_error": "qualitative", "text_access": "abstract_only", "n_definition": "axon–dendrite contacts evaluated in EM volume", "scope_region": "V1, local L2/3 microcircuit", "study_system": "mouse V1 L2/3; functional-EM (calcium imaging + ssEM)", "taxonomic_level": "cell-class", "scope_population": "L2/3 pyramidal neurons", "value_source_sentence": "More specifically, we found that pyramidal neurons with similar orientation selectivity preferentially formed synapses with each other, despite the fact that axons and dendrites of all orientation selectivities pass near (<5 μm) each other with roughly equal probability.", "experimental_conditions": "adult mice" }, { "n": 0, "doi": "10.1038/s41586-025-08840-3", "value": "like-to-like extends across layers/areas including feedback; only feature (not spatial) component predicts connections", "method": "millimetre-scale functional connectomics", "metric": "feature-similarity dependence of fine-scale connectivity (MICrONS scale)", "n_analyzed": "not in abstract", "ci_or_error": "qualitative across areas/layers", "text_access": "abstract_only", "n_definition": "millimetre-scale connectomic dataset (MICrONS)", "scope_region": "V1 + higher visual areas", "study_system": "mouse visual cortex; large-volume EM + functional imaging", "taxonomic_level": "cell-class/layer/area", "scope_population": "excitatory neurons across layers", "value_source_sentence": "Our results reveal that neurons with similar response properties are preferentially connected within and across layers and areas-including feedback connections-supporting the universality of 'like-to-like' connectivity across the visual hierarchy.", "experimental_conditions": "adult mice (MICrONS preparation)" } ], "audit_issues": [ { "dimension": "metric_definition", "description": "Rows mix P(conn) trend with ΔOri (Ko 2011, p-value), EPSP-vs-correlation distribution (Cossell 2015), EM synapse preference (Lee 2016), and feature-similarity gradient (MICrONS). All probe like-to-like wiring but yield non-comparable scalar statistics.", "entries_affected": [ "10.1038/nature09880", "10.1038/nature14182", "10.1038/nature17192", "10.1038/s41586-025-08840-3" ] }, { "dimension": "scope_region", "description": "MICrONS spans V1 + multiple higher visual areas across layers; the other three are local V1 L2/3 only.", "entries_affected": [ "10.1038/s41586-025-08840-3", "10.1038/nature09880", "10.1038/nature14182", "10.1038/nature17192" ] } ], "audit_verdict": "CAVEAT", "comparison_id": "like-to-like-p-connection", "comparison_name": "Like-to-like excitatory connectivity by tuning similarity in mouse V1", "comparison_type": "convergent evidence", "what_it_reveals": "Convergent evidence across paired recordings, functional EM of L2/3, and millimetre-scale connectomics that excitatory-to-excitatory wiring in mouse V1 is biased by tuning similarity — most strongly for the few large-amplitude connections — and that the rule extends across layers and visual areas.", "homogeneity_check": { "caveats": [ "Methods span paired recordings, functional EM, and millimetre-scale connectomics; n-definitions therefore differ.", "First three entries are confined to local L2/3 V1; MICrONS extends to other layers and inter-areal feedback connections — comparison spans broader scope." ], "n_definition_uniform": "false", "scope_region_uniform": "false", "taxonomic_level_uniform": "true", "scope_population_uniform": "true" }, "suggested_plot_type": "forest plot", "mandatory_caption_caveats": [ "Like-to-like is measured by different statistics across studies (P(conn) trend, EPSP–correlation distribution, EM synapse preference, feature-similarity gradient); rows are not averageable.", "MICrONS covers V1 + higher visual areas, layers 2–6, including feedback; the other rows are local V1 L2/3." ] }, "section_id": "section_05", "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_05_evidence_package.json", "target_ref": "wiki_page:computationalreviewrecurrence-05-horizontal", "review_repo": "ComputationalReviewRecurrence", "section_ref": "wiki_page:computationalreviewrecurrence-05-horizontal", "source_path": "evidence/section_05_evidence_package.json", "source_refs": [ "paper:paper-31c9e0b4d258", "paper:paper-7ac22819c082", "paper:paper-c4ad527c9bfb", "paper:paper-d2a8c6775359" ], "section_title": "5. Horizontal long-range intracortical excitatory connections in mouse — patchy L2/3-L5 axons, similarity tuning, distance-decay", "source_policy": { "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence" }, "generation_status": "complete", "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9", "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_05_evidence_package.json", "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f", "created_by": "persona-jerome-lecoq-gbo-neuroscience", "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence" }