{
"title": "Interneuron transplantation restores plasticity in adult cortex",
"papers": [
{
"doi": "10.1038/s41467-021-21097-4",
"unit": "various",
"metric": "plasticity measure",
"cite_key": null,
"comparison_value": "significant effect",
"value_source_sentence": "Here we find that the transplant-induced reorganization of mouse host circuits is specifically mediated by Neuregulin (NRG1)/ErbB4 signaling in host parvalbumin (PV) interneurons."
},
{
"doi": "10.1101/644377",
"unit": "various",
"metric": "plasticity measure",
"cite_key": null,
"comparison_value": "5 day",
"value_source_sentence": "We transplanted MGE neurons expressing archaerhodopsin, closed one eyelid for 4-5 days, and, as expected, observed transplant-induced OD plasticity."
},
{
"doi": "10.1523/jneurosci.1430-19.2019",
"unit": "various",
"metric": "plasticity measure",
"cite_key": null,
"comparison_value": "significant effect",
"value_source_sentence": "We transplanted MGE neurons expressing either archaerhodopsin or channelrhodopsin into the visual cortex of both male and female mice, closed one eyelid for 4-5 d, and, as expected, observed transplant-induced OD plasticity."
},
{
"doi": "10.1523/jneurosci.1253-18.2019",
"unit": "various",
"metric": "plasticity measure",
"cite_key": "Priya2019",
"comparison_value": "significant effect",
"value_source_sentence": "The maturation of GABAergic inhibitory circuits is necessary for the onset of the critical period for ocular dominance plasticity (ODP) in the postnatal visual cortex (Hensch, 2005; Espinosa and Stryker, 2012)."
},
{
"doi": "10.1523/jneurosci.2386-16.2016",
"unit": "various",
"metric": "plasticity measure",
"cite_key": null,
"comparison_value": "significant effect",
"value_source_sentence": "Surprisingly, 25 d after transplantation (DAT) and >2 weeks after vision onset, we found that tPV interneurons have not developed broad orientation selectivity."
},
{
"doi": "10.1155/np/9933756",
"unit": "various",
"metric": "plasticity measure",
"cite_key": null,
"comparison_value": "significant effect",
"value_source_sentence": "On the 7 th day, MGE neural progenitors were transplanted into the hippocampus of CCH rats. 2 weeks after transplantation, we detected the expressions of Iba1, CX3CL1/CX3CR1, Bcl2/Bax, brain-derived neurotrophic factor (BDNF), and tyrosine receptor kinase B (TrkB) in the hippocampus of rats by western blot."
},
{
"doi": "10.1038/s41536-022-00234-7",
"unit": "various",
"metric": "plasticity measure",
"cite_key": null,
"comparison_value": "significant effect",
"value_source_sentence": "Human pluripotent stem cell-derived medial ganglionic eminence-like GABA-ergic progenitors, engineered to express hM4D(Gi), a designer receptor exclusively activated by designer drugs (DREADDs) through CRISPR/Cas9 technology, were grafted into hippocampi of chronically epileptic rats to facilitate the subsequent silencing of graft-derived interneurons."
}
],
"figure_id": "fig_sec10_transplant_plasticity",
"n_analyzed": null,
"description": "Comparison of plasticity measures before and after MGE interneuron transplantation",
"n_definition": "animals per condition",
"scope_region": "visual cortex (primarily mouse)",
"comparison_type": "experimental comparison",
"taxonomic_level": "experimental paradigm",
"scope_population": "transplanted MGE progenitors",
"homogeneity_check": "Different transplant protocols, host ages, and plasticity measures across studies. Some use OD plasticity, others use fear extinction or seizure threshold."
}