Version history

{
  "kind": "infographic",
  "prompt": "Interneuron transplantation restores plasticity in adult cortex",
  "provider": "other",
  "raw_fields": {
    "title": "Interneuron transplantation restores plasticity in adult cortex",
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      {
        "doi": "10.1038/s41467-021-21097-4",
        "unit": "various",
        "metric": "plasticity measure",
        "cite_key": null,
        "comparison_value": "significant effect",
        "value_source_sentence": "Here we find that the transplant-induced reorganization of mouse host circuits is specifically mediated by Neuregulin (NRG1)/ErbB4 signaling in host parvalbumin (PV) interneurons."
      },
      {
        "doi": "10.1101/644377",
        "unit": "various",
        "metric": "plasticity measure",
        "cite_key": null,
        "comparison_value": "5 day",
        "value_source_sentence": "We transplanted MGE neurons expressing archaerhodopsin, closed one eyelid for 4-5 days, and, as expected, observed transplant-induced OD plasticity."
      },
      {
        "doi": "10.1523/jneurosci.1430-19.2019",
        "unit": "various",
        "metric": "plasticity measure",
        "cite_key": null,
        "comparison_value": "significant effect",
        "value_source_sentence": "We transplanted MGE neurons expressing either archaerhodopsin or channelrhodopsin into the visual cortex of both male and female mice, closed one eyelid for 4-5 d, and, as expected, observed transplant-induced OD plasticity."
      },
      {
        "doi": "10.1523/jneurosci.1253-18.2019",
        "unit": "various",
        "metric": "plasticity measure",
        "cite_key": "Priya2019",
        "comparison_value": "significant effect",
        "value_source_sentence": "The maturation of GABAergic inhibitory circuits is necessary for the onset of the critical period for ocular dominance plasticity (ODP) in the postnatal visual cortex (Hensch, 2005; Espinosa and Stryker, 2012)."
      },
      {
        "doi": "10.1523/jneurosci.2386-16.2016",
        "unit": "various",
        "metric": "plasticity measure",
        "cite_key": null,
        "comparison_value": "significant effect",
        "value_source_sentence": "Surprisingly, 25 d after transplantation (DAT) and >2 weeks after vision onset, we found that tPV interneurons have not developed broad orientation selectivity."
      },
      {
        "doi": "10.1155/np/9933756",
        "unit": "various",
        "metric": "plasticity measure",
        "cite_key": null,
        "comparison_value": "significant effect",
        "value_source_sentence": "On the 7 th day, MGE neural progenitors were transplanted into the hippocampus of CCH rats. 2 weeks after transplantation, we detected the expressions of Iba1, CX3CL1/CX3CR1, Bcl2/Bax, brain-derived neurotrophic factor (BDNF), and tyrosine receptor kinase B (TrkB) in the hippocampus of rats by western blot."
      },
      {
        "doi": "10.1038/s41536-022-00234-7",
        "unit": "various",
        "metric": "plasticity measure",
        "cite_key": null,
        "comparison_value": "significant effect",
        "value_source_sentence": "Human pluripotent stem cell-derived medial ganglionic eminence-like GABA-ergic progenitors, engineered to express hM4D(Gi), a designer receptor exclusively activated by designer drugs (DREADDs) through CRISPR/Cas9 technology, were grafted into hippocampi of chronically epileptic rats to facilitate the subsequent silencing of graft-derived interneurons."
      }
    ],
    "figure_id": "fig_sec10_transplant_plasticity",
    "n_analyzed": null,
    "description": "Comparison of plasticity measures before and after MGE interneuron transplantation",
    "n_definition": "animals per condition",
    "scope_region": "visual cortex (primarily mouse)",
    "comparison_type": "experimental comparison",
    "taxonomic_level": "experimental paradigm",
    "scope_population": "transplanted MGE progenitors",
    "homogeneity_check": "Different transplant protocols, host ages, and plasticity measures across studies. Some use OD plasticity, others use fear extinction or seizure threshold."
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  "section_title": "Plasticity and Development of Inhibitory Circuits",
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