Version history

{
  "kind": "infographic",
  "prompt": "D1 vs D2 MSN activity during cocaine self-administration phases",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "doi": "10.1523/jneurosci.0108-23.2023",
        "value": "significant change",
        "method": "calcium imaging",
        "cite_key": "Kokane2023",
        "value_source_sentence": "Heroin abstinence significantly increased intrinsic excitability in D1<sup>+</sup> and D2<sup>+</sup> PL->NAc neurons and increased postsynaptic strength selectively in D1<sup>+</sup> neurons."
      }
    ],
    "x_axis": "Drug-taking phase",
    "y_axis": "Calcium signal (ΔF/F or z-score)",
    "n_analyzed": "varies by study",
    "n_definition": "animals with validated cell-type targeting",
    "scope_region": "nucleus accumbens",
    "comparison_name": "D1 vs D2 MSN activity during cocaine self-administration phases",
    "comparison_type": "cell-type comparison",
    "taxonomic_level": "cell type (Cre-defined)",
    "scope_population": "D1-MSNs and D2-MSNs",
    "homogeneity_check": "Studies use different Cre lines (D1-Cre vs Drd1-Cre), different calcium indicators (GCaMP6 vs GCaMP7), and different self-administration schedules. Direct comparison of magnitudes requires careful normalization."
  },
  "section_id": "section_07_evidence",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction/blob/43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48/evidence/section_07_evidence.json",
  "target_ref": "wiki_page:computationalreviewaddiction-07",
  "review_repo": "ComputationalReviewAddiction",
  "section_ref": "wiki_page:computationalreviewaddiction-07",
  "source_path": "evidence/section_07_evidence.json",
  "source_refs": [
    "paper:paper-2a36d047f211"
  ],
  "section_title": "Recording Realities: What In Vivo Technologies Reveal and Conceal",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction"
  },
  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-d95cfb705572",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction/blob/43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48/evidence/section_07_evidence.json",
  "commit_sha": "43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction"
}