{
"papers": [
{
"n": null,
"doi": "10.1523/jneurosci.2700-20.2021",
"value": "22%",
"cite_key": "Vereczki2021",
"n_definition": "number of recordings or cell pairs",
"scope_region": "cortex / hippocampus",
"scope_population": "chandelier cells → pyramidal neurons",
"value_source_sentence": "Using unbiased stereology, we found that the ratio of GABAergic neurons in the BA (22%) is significantly higher than in the LA (16%) in both male and female mice."
},
{
"n": null,
"doi": "10.1093/cercor/7.6.476",
"value": "28 (from abstract context)",
"cite_key": "Kawaguchi1997",
"n_definition": "number of recordings or cell pairs",
"scope_region": "cortex / hippocampus",
"scope_population": "chandelier cells → pyramidal neurons",
"value_source_sentence": "Both these physiological types corresponded to a range of morphologies: (i) somatostatin-containing Martinotti cells with ascending axonal arbors to layer I (some were also positive for calbindin D28k); (ii) VIP-containing double bouquet cells with descending axonal arbors as well as arcade cells (these included small cells immunoreactive for CCK or calretinin)."
},
{
"n": null,
"doi": "10.1523/jneurosci.0908-08.2008",
"value": "2006 (from abstract context)",
"cite_key": "Khirug2008",
"n_definition": "number of recordings or cell pairs",
"scope_region": "cortex / hippocampus",
"scope_population": "chandelier cells → pyramidal neurons",
"value_source_sentence": "However, recent work (Szabadics et al., 2006) indicates that this input from AACs can be depolarizing and even excitatory."
},
{
"n": null,
"doi": "10.3389/fnmol.2019.00154",
"value": "2 (from abstract context)",
"cite_key": "Contreras2019",
"n_definition": "number of recordings or cell pairs",
"scope_region": "cortex / hippocampus",
"scope_population": "chandelier cells → pyramidal neurons",
"value_source_sentence": "Unique presynaptic molecular contributors, <i>LGI2</i> and <i>FGF13</i>, expressed in parvalbumin positive basket cells and chandelier cells, respectively, have also recently been identified."
},
{
"n": null,
"doi": "10.14712/fb2009055060201",
"value": "25 % of",
"cite_key": "Druga2009",
"n_definition": "number of recordings or cell pairs",
"scope_region": "cortex / hippocampus",
"scope_population": "chandelier cells → pyramidal neurons",
"value_source_sentence": "GABAergic, inhibitory interneurons are morphologically distinct from excitatory pyramidal cells and account for 20-25 % of all neocortical neurons."
},
{
"n": null,
"doi": "10.1523/jneurosci.23-07-02759.2003",
"value": "25 ms",
"cite_key": "Sayin2003",
"n_definition": "number of recordings or cell pairs",
"scope_region": "cortex / hippocampus",
"scope_population": "chandelier cells → pyramidal neurons",
"value_source_sentence": "Previous studies have demonstrated that the initial seizures evoked by kindling increase paired-pulse inhibition at 15-25 msec interpulse intervals in the dentate gyrus and also induce apoptosis, progressive neuronal loss, mossy fiber sprouting, and neurogenesis, which could potentially alter the balance of excitation and/or inhibition and modify functional properties of hippocampal circuits."
}
],
"x_axis": "Study",
"y_axis": "Postsynaptic effect (depolarization vs hyperpolarization)",
"n_analyzed": "varies",
"n_definition": "number of paired recordings",
"scope_region": "cortex and hippocampus",
"comparison_name": "Chandelier cell postsynaptic effects across studies",
"comparison_type": "cross_study_conflict",
"taxonomic_level": "chandelier cell class (PV+)",
"scope_population": "chandelier cells / axo-axonic cells",
"homogeneity_check": {
"caveats": [
"Different recording conditions (whole-cell vs perforated patch)",
"Different chloride concentrations in internal solutions",
"Different brain regions and layers",
"Different developmental ages",
"Critical dependence on intact chloride gradients - some methods disrupt these"
],
"comparable": false
}
}