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(ii) VIP-containing double bouquet cells with descending axonal arbors as well as arcade cells (these included small cells immunoreactive for CCK or calretinin)." }, { "n": null, "doi": "10.1523/jneurosci.0908-08.2008", "value": "2006 (from abstract context)", "cite_key": "Khirug2008", "n_definition": "number of recordings or cell pairs", "scope_region": "cortex / hippocampus", "scope_population": "chandelier cells → pyramidal neurons", "value_source_sentence": "However, recent work (Szabadics et al., 2006) indicates that this input from AACs can be depolarizing and even excitatory." }, { "n": null, "doi": "10.3389/fnmol.2019.00154", "value": "2 (from abstract context)", "cite_key": "Contreras2019", "n_definition": "number of recordings or cell pairs", "scope_region": "cortex / hippocampus", "scope_population": "chandelier cells → pyramidal neurons", "value_source_sentence": "Unique presynaptic molecular contributors, <i>LGI2</i> and <i>FGF13</i>, expressed in parvalbumin positive basket cells and chandelier cells, respectively, have also recently been identified." }, { "n": null, "doi": "10.14712/fb2009055060201", "value": "25 % of", "cite_key": "Druga2009", "n_definition": "number of recordings or cell pairs", "scope_region": "cortex / hippocampus", "scope_population": "chandelier cells → pyramidal neurons", "value_source_sentence": "GABAergic, inhibitory interneurons are morphologically distinct from excitatory pyramidal cells and account for 20-25 % of all neocortical neurons." }, { "n": null, "doi": "10.1523/jneurosci.23-07-02759.2003", "value": "25 ms", "cite_key": "Sayin2003", "n_definition": "number of recordings or cell pairs", "scope_region": "cortex / hippocampus", "scope_population": "chandelier cells → pyramidal neurons", "value_source_sentence": "Previous studies have demonstrated that the initial seizures evoked by kindling increase paired-pulse inhibition at 15-25 msec interpulse intervals in the dentate gyrus and also induce apoptosis, progressive neuronal loss, mossy fiber sprouting, and neurogenesis, which could potentially alter the balance of excitation and/or inhibition and modify functional properties of hippocampal circuits." } ], "x_axis": "Study", "y_axis": "Postsynaptic effect (depolarization vs hyperpolarization)", "n_analyzed": "varies", "n_definition": "number of paired recordings", "scope_region": "cortex and hippocampus", "comparison_name": "Chandelier cell postsynaptic effects across studies", "comparison_type": "cross_study_conflict", "taxonomic_level": "chandelier cell class (PV+)", "scope_population": "chandelier cells / axo-axonic cells", "homogeneity_check": { "caveats": [ "Different recording conditions (whole-cell vs perforated patch)", "Different chloride concentrations in internal solutions", "Different brain regions and layers", "Different developmental ages", "Critical dependence on intact chloride gradients - some methods disrupt these" ], "comparable": false } }, "section_id": "section_06_evidence", "source_url": "https://github.com/AllenNeuralDynamics/ComputationReviewInhibitory/blob/934e0675cc6d5ffd9978a4a9883b31166ce000e2/evidence/section_06_evidence.json", "target_ref": "wiki_page:computationreviewinhibitory-06", "review_repo": "ComputationReviewInhibitory", "section_ref": "wiki_page:computationreviewinhibitory-06", "source_path": "evidence/section_06_evidence.json", "source_refs": [ "paper:paper-0506337fc9e9", "paper:paper-205603bfaf82", "paper:paper-2cd62c7ab4ba", "paper:paper-3d014890c700", "paper:paper-3f63e12bf8c8", "paper:paper-5bc62b85e3e7" ], "section_title": "VIP Interneuron Function and Disinhibition", "source_policy": { "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; 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