Version history

{
  "kind": "infographic",
  "prompt": "Vulnerability, Development, and Individual Differences: Why Not Everyone Becomes Addicted figure 2",
  "provider": "other",
  "raw_fields": {
    "name": "Sign-tracker vs goal-tracker: dopamine and behavioral differences",
    "papers": [
      {
        "doi": "10.1016/j.neubiorev.2020.01.018",
        "value": null,
        "cite_key": "Colaizzi2020",
        "n_analyzed": null,
        "n_definition": "animals phenotyped as ST or GT",
        "scope_region": "nucleus accumbens / VTA",
        "scope_population": "outbred rats (Sprague-Dawley or Long-Evans)",
        "value_source_sentence": "Whereas goal-trackers are biased toward the outcome, sign-trackers fixate on features that are associated with but not necessary for achieving an outcome; a pattern of behavior that often leads to escalation of reward-seeking that can be maladaptive."
      },
      {
        "doi": "10.1111/jnc.13524",
        "value": "p>1",
        "cite_key": "Fitzpatrick2016",
        "n_analyzed": null,
        "n_definition": "animals phenotyped as ST or GT",
        "scope_region": "nucleus accumbens / VTA",
        "scope_population": "outbred rats (Sprague-Dawley or Long-Evans)",
        "value_source_sentence": "Levels of myo-inositol (Ins), a <sup>1</sup> H-MRS-detectable marker of glial activity/proliferation, were increased in the nucleus accumbens (NAc) and ventral hippocampus, but not dorsal hippocampus or medial prefrontal cortex, of sign-trackers compared to goal-trackers or intermediate responders."
      },
      {
        "doi": "10.3389/fpsyg.2024.1416222",
        "value": null,
        "cite_key": "Su2024",
        "n_analyzed": null,
        "n_definition": "animals phenotyped as ST or GT",
        "scope_region": "nucleus accumbens / VTA",
        "scope_population": "outbred rats (Sprague-Dawley or Long-Evans)",
        "value_source_sentence": "Differences observed in Sign-trackers (ST) and Goal-trackers (GT) during Pavlovian conditioning may shed light on individual variances in drug addiction."
      },
      {
        "doi": "10.1523/jneurosci.1486-22.2023",
        "value": null,
        "cite_key": "Bacharach2023",
        "n_analyzed": null,
        "n_definition": "animals phenotyped as ST or GT",
        "scope_region": "nucleus accumbens / VTA",
        "scope_population": "outbred rats (Sprague-Dawley or Long-Evans)",
        "value_source_sentence": "Our results suggest that CB1R signaling in the VTA influences the balance between the conditioned stimulus-evoked and US-evoked dopamine responses in the NAc shell and biases behavioral responding to cues in sign-tracking rats.<b>SIGNIFICANCE STATEMENT</b> Substance use disorder (SUD) is a chronically relapsing psychological disorder that affects a subset of individuals who engage in drug use."
      }
    ],
    "n_definition": "rats classified by phenotype",
    "scope_region": "nucleus accumbens",
    "comparison_type": "phenotype_comparison",
    "taxonomic_level": "N/A",
    "scope_population": "outbred rats",
    "homogeneity_check": "Studies use different rat strains and behavioral paradigms for ST/GT classification. Dopamine measurements span microdialysis and voltammetry. Cross-study quantitative comparison limited."
  },
  "section_id": "section_10_evidence",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction/blob/43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48/evidence/section_10_evidence.json",
  "target_ref": "wiki_page:computationalreviewaddiction-10",
  "review_repo": "ComputationalReviewAddiction",
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  "source_path": "evidence/section_10_evidence.json",
  "source_refs": [
    "paper:paper-019e3d3726d1",
    "paper:paper-4e612d903979",
    "paper:paper-b73dc0503e94",
    "paper:paper-f00c3605bcd9"
  ],
  "section_title": "Vulnerability, Development, and Individual Differences: Why Not Everyone Becomes Addicted",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction"
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  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-d95cfb705572",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction/blob/43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48/evidence/section_10_evidence.json",
  "commit_sha": "43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction"
}