D1 vs D2 MSN Encoding of Reward Distribution Components

{
  "title": "D1 vs D2 MSN Encoding of Reward Distribution Components",
  "papers": [
    {
      "n": 12,
      "doi": "10.1038/s41586-024-08488-5",
      "value": "D1 MSNs preferentially encode right tail of reward distribution",
      "region": "Lateral accumbens shell (lAcbSh)",
      "text_access": "fulltext",
      "study_system": "mouse",
      "value_source_sentence": "Two-photon calcium imaging and optogenetics revealed that the two major classes of striatal medium spiny neurons — D1 and D2 MSNs — contributed to this code by preferentially encoding the right and left tails of the reward distribution, respectively."
    },
    {
      "n": 12,
      "doi": "10.1038/s41586-024-08488-5",
      "value": "D2 MSNs preferentially encode left tail of reward distribution",
      "region": "Lateral accumbens shell (lAcbSh)",
      "text_access": "fulltext",
      "study_system": "mouse",
      "value_source_sentence": "Two-photon calcium imaging and optogenetics revealed that the two major classes of striatal medium spiny neurons — D1 and D2 MSNs — contributed to this code by preferentially encoding the right and left tails of the reward distribution, respectively."
    },
    {
      "n": 12,
      "doi": "10.1038/s41586-024-08488-5",
      "value": "Dopamine ablation disorganizes distributional but not mean value representations; 13,997 neurons recorded",
      "region": "Striatum (Neuropixels recordings)",
      "text_access": "fulltext",
      "study_system": "mouse",
      "value_source_sentence": "Remarkably, chronic ablation of dopamine inputs disorganized these distributional representations in the striatum without interfering with mean value coding."
    }
  ],
  "x_axis": "MSN subtype",
  "y_axis": "Distributional encoding properties",
  "n_analyzed": "N=12 mice, 13,997 neurons (Neuropixels); N=4 mice per genotype (2-photon)",
  "description": "Comparison of how D1-MSNs and D2-MSNs encode different aspects of reward probability distributions in the striatum",
  "figure_type": "opponent_comparison",
  "n_definition": "N = mice, n = sessions/neurons",
  "scope_region": "Ventral striatum / nucleus accumbens",
  "comparison_id": "D1_D2_MSN_distributional_coding",
  "taxonomic_level": "cell-type specific (Cre-lines)",
  "scope_population": "D1-MSN and D2-MSN populations identified genetically",
  "homogeneity_check": "All data from single study. Mouse model with Cre-dependent reporters. Two-photon and Neuropixels are complementary approaches within same paradigm. Optogenetic validation adds causal evidence. Caveat: classical conditioning only, limited behavioral complexity."
}

[
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]

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