Version history

{
  "kind": "infographic",
  "prompt": "D1 vs D2 MSN Encoding of Reward Distribution Components",
  "provider": "other",
  "raw_fields": {
    "title": "D1 vs D2 MSN Encoding of Reward Distribution Components",
    "papers": [
      {
        "n": 12,
        "doi": "10.1038/s41586-024-08488-5",
        "value": "D1 MSNs preferentially encode right tail of reward distribution",
        "region": "Lateral accumbens shell (lAcbSh)",
        "text_access": "fulltext",
        "study_system": "mouse",
        "value_source_sentence": "Two-photon calcium imaging and optogenetics revealed that the two major classes of striatal medium spiny neurons — D1 and D2 MSNs — contributed to this code by preferentially encoding the right and left tails of the reward distribution, respectively."
      },
      {
        "n": 12,
        "doi": "10.1038/s41586-024-08488-5",
        "value": "D2 MSNs preferentially encode left tail of reward distribution",
        "region": "Lateral accumbens shell (lAcbSh)",
        "text_access": "fulltext",
        "study_system": "mouse",
        "value_source_sentence": "Two-photon calcium imaging and optogenetics revealed that the two major classes of striatal medium spiny neurons — D1 and D2 MSNs — contributed to this code by preferentially encoding the right and left tails of the reward distribution, respectively."
      },
      {
        "n": 12,
        "doi": "10.1038/s41586-024-08488-5",
        "value": "Dopamine ablation disorganizes distributional but not mean value representations; 13,997 neurons recorded",
        "region": "Striatum (Neuropixels recordings)",
        "text_access": "fulltext",
        "study_system": "mouse",
        "value_source_sentence": "Remarkably, chronic ablation of dopamine inputs disorganized these distributional representations in the striatum without interfering with mean value coding."
      }
    ],
    "x_axis": "MSN subtype",
    "y_axis": "Distributional encoding properties",
    "n_analyzed": "N=12 mice, 13,997 neurons (Neuropixels); N=4 mice per genotype (2-photon)",
    "description": "Comparison of how D1-MSNs and D2-MSNs encode different aspects of reward probability distributions in the striatum",
    "figure_type": "opponent_comparison",
    "n_definition": "N = mice, n = sessions/neurons",
    "scope_region": "Ventral striatum / nucleus accumbens",
    "comparison_id": "D1_D2_MSN_distributional_coding",
    "taxonomic_level": "cell-type specific (Cre-lines)",
    "scope_population": "D1-MSN and D2-MSN populations identified genetically",
    "homogeneity_check": "All data from single study. Mouse model with Cre-dependent reporters. Two-photon and Neuropixels are complementary approaches within same paradigm. Optogenetic validation adds causal evidence. Caveat: classical conditioning only, limited behavioral complexity."
  },
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  "section_title": "Dopamine: From Reward Signal to Brain-Wide Modulator",
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      "Local review repositories are read-only inputs.",
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}