Details

kind
infographic
prompt
Molecular Adaptations: Synaptic Plasticity, Transcriptional Cascades, and Epigenetic Mechanisms figure 2
provider
other
section_id
section_03_evidence
source_url
https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction/blob/43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48/evidence/section_03_evidence.json
target_ref
wiki_page:computationalreviewaddiction-03
review_repo
ComputationalReviewAddiction
section_ref
wiki_page:computationalreviewaddiction-03
source_path
evidence/section_03_evidence.json
section_title
Molecular Adaptations: Synaptic Plasticity, Transcriptional Cascades, and Epigenetic Mechanisms
generation_status
complete
review_bundle_ref
analysis_bundle:ab-d95cfb705572
origin_url
https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction/blob/43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48/evidence/section_03_evidence.json
commit_sha
43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48
created_by
persona-jerome-lecoq-gbo-neuroscience
repository_url
https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction
Raw fields (3)
raw_fields
{
  "papers": [
    {
      "n": 135,
      "doi": "10.1523/eneuro.0480-22.2023",
      "value": "p  = 0.051",
      "metric": "CP-AMPA rectification index or silent synapse fraction",
      "cite_key": "Funke2023",
      "text_access": "fulltext",
      "study_system": "rat",
      "value_source_sentence": "05, ^ p  = 0.051."
    },
    {
      "n": 14,
      "doi": "10.1038/s41398-021-01658-3",
      "value": "P  = 0.0262",
      "metric": "CP-AMPA rectification index or silent synapse fraction",
      "cite_key": "Skiteva2021",
      "text_access": "fulltext",
      "study_system": "mouse",
      "value_source_sentence": "§ P  = 0.0262, two-way ANOVA."
    },
    {
      "n": 14,
      "doi": "10.3389/fnsyn.2018.00036",
      "value": "p  = 0.008",
      "metric": "CP-AMPA rectification index or silent synapse fraction",
      "cite_key": "Scheyer2018",
      "text_access": "fulltext",
      "study_system": "rat",
      "value_source_sentence": "71,  p  = 0.008; ** p  < 0."
    },
    {
      "n": 9,
      "doi": "10.3389/fpsyt.2025.1627477",
      "value": "p=0.906",
      "metric": "CP-AMPA rectification index or silent synapse fraction",
      "cite_key": "HuertaSanchez2025",
      "text_access": "fulltext",
      "study_system": "rat",
      "value_source_sentence": "014, p=0.906], inactive lever-presses [F(5,33)=2,457, p=0."
    },
    {
      "n": 201,
      "doi": "10.1113/jp279029",
      "value": "100 ms",
      "metric": "CP-AMPA rectification index or silent synapse fraction",
      "cite_key": "CullCandy2021",
      "text_access": "fulltext",
      "study_system": "rat",
      "value_source_sentence": "Right, representative responses from granule cell outside‐out patches to application of AMPA (1 m m , 100 ms, −60 mV)."
    },
    {
      "n": 26,
      "doi": "10.1038/s41386-020-0781-1",
      "value": "p  = 0.0003",
      "metric": "CP-AMPA rectification index or silent synapse fraction",
      "cite_key": "AlonsoCaraballo2021",
      "text_access": "fulltext",
      "study_system": "rat",
      "value_source_sentence": "1,  p  = 0.0003; main effect of group  F  (1,36)  = 16."
    },
    {
      "n": 10,
      "doi": "10.1126/sciadv.add6642",
      "value": "1.90 mm",
      "metric": "CP-AMPA rectification index or silent synapse fraction",
      "cite_key": "Lv2022",
      "text_access": "fulltext",
      "study_system": "rat",
      "value_source_sentence": "Brain coordinates of injections were chosen in accordance with the mouse brain atlas: PL-mPFC [anterior-posterior (AP): +1.90 mm; medial-lateral (ML): ±0."
    }
  ],
  "n_definition": "cells recorded or animals per group",
  "scope_region": "Nucleus accumbens (core and shell)",
  "comparison_id": "fig_sec3_cpampa_incubation",
  "comparison_type": "cross-study",
  "scope_population": "medium spiny neurons D1 and D2 type",
  "homogeneity_check": {
    "caveats": [
      "Mix of cocaine and opioid self-administration studies",
      "Different withdrawal durations (1 day vs 45 days)",
      "Different measures: rectification index, silent synapse fraction, mEPSC amplitude",
      "Both core and shell subregions of NAc represented"
    ],
    "comparable": true
  },
  "suggested_plot_type": "grouped_bar"
}
source_refs
[
  "paper:paper-1371db6808d9",
  "paper:paper-1f49dd448dc5",
  "paper:paper-2248e4f398ca",
  "paper:paper-2a99f9635846",
  "paper:paper-a934f98b5b23",
  "paper:paper-b5ef24926749",
  "paper:paper-dc03de1ebe17"
]
source_policy
{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction"
}

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