Version history

1 version on record. Newest first; the live version sits at the top with a live indicator.

  1. Live bf0197a83fec
    5/17/2026, 4:35:28 PM
    Content snapshot
    {
      "kind": "infographic",
      "prompt": "Molecular Adaptations: Synaptic Plasticity, Transcriptional Cascades, and Epigenetic Mechanisms figure 2",
      "provider": "other",
      "raw_fields": {
        "papers": [
          {
            "n": 135,
            "doi": "10.1523/eneuro.0480-22.2023",
            "value": "p  = 0.051",
            "metric": "CP-AMPA rectification index or silent synapse fraction",
            "cite_key": "Funke2023",
            "text_access": "fulltext",
            "study_system": "rat",
            "value_source_sentence": "05, ^ p  = 0.051."
          },
          {
            "n": 14,
            "doi": "10.1038/s41398-021-01658-3",
            "value": "P  = 0.0262",
            "metric": "CP-AMPA rectification index or silent synapse fraction",
            "cite_key": "Skiteva2021",
            "text_access": "fulltext",
            "study_system": "mouse",
            "value_source_sentence": "§ P  = 0.0262, two-way ANOVA."
          },
          {
            "n": 14,
            "doi": "10.3389/fnsyn.2018.00036",
            "value": "p  = 0.008",
            "metric": "CP-AMPA rectification index or silent synapse fraction",
            "cite_key": "Scheyer2018",
            "text_access": "fulltext",
            "study_system": "rat",
            "value_source_sentence": "71,  p  = 0.008; ** p  < 0."
          },
          {
            "n": 9,
            "doi": "10.3389/fpsyt.2025.1627477",
            "value": "p=0.906",
            "metric": "CP-AMPA rectification index or silent synapse fraction",
            "cite_key": "HuertaSanchez2025",
            "text_access": "fulltext",
            "study_system": "rat",
            "value_source_sentence": "014, p=0.906], inactive lever-presses [F(5,33)=2,457, p=0."
          },
          {
            "n": 201,
            "doi": "10.1113/jp279029",
            "value": "100 ms",
            "metric": "CP-AMPA rectification index or silent synapse fraction",
            "cite_key": "CullCandy2021",
            "text_access": "fulltext",
            "study_system": "rat",
            "value_source_sentence": "Right, representative responses from granule cell outside‐out patches to application of AMPA (1 m m , 100 ms, −60 mV)."
          },
          {
            "n": 26,
            "doi": "10.1038/s41386-020-0781-1",
            "value": "p  = 0.0003",
            "metric": "CP-AMPA rectification index or silent synapse fraction",
            "cite_key": "AlonsoCaraballo2021",
            "text_access": "fulltext",
            "study_system": "rat",
            "value_source_sentence": "1,  p  = 0.0003; main effect of group  F  (1,36)  = 16."
          },
          {
            "n": 10,
            "doi": "10.1126/sciadv.add6642",
            "value": "1.90 mm",
            "metric": "CP-AMPA rectification index or silent synapse fraction",
            "cite_key": "Lv2022",
            "text_access": "fulltext",
            "study_system": "rat",
            "value_source_sentence": "Brain coordinates of injections were chosen in accordance with the mouse brain atlas: PL-mPFC [anterior-posterior (AP): +1.90 mm; medial-lateral (ML): ±0."
          }
        ],
        "n_definition": "cells recorded or animals per group",
        "scope_region": "Nucleus accumbens (core and shell)",
        "comparison_id": "fig_sec3_cpampa_incubation",
        "comparison_type": "cross-study",
        "scope_population": "medium spiny neurons D1 and D2 type",
        "homogeneity_check": {
          "caveats": [
            "Mix of cocaine and opioid self-administration studies",
            "Different withdrawal durations (1 day vs 45 days)",
            "Different measures: rectification index, silent synapse fraction, mEPSC amplitude",
            "Both core and shell subregions of NAc represented"
          ],
          "comparable": true
        },
        "suggested_plot_type": "grouped_bar"
      },
      "section_id": "section_03_evidence",
      "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction/blob/43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48/evidence/section_03_evidence.json",
      "target_ref": "wiki_page:computationalreviewaddiction-03",
      "review_repo": "ComputationalReviewAddiction",
      "section_ref": "wiki_page:computationalreviewaddiction-03",
      "source_path": "evidence/section_03_evidence.json",
      "source_refs": [
        "paper:paper-1371db6808d9",
        "paper:paper-1f49dd448dc5",
        "paper:paper-2248e4f398ca",
        "paper:paper-2a99f9635846",
        "paper:paper-a934f98b5b23",
        "paper:paper-b5ef24926749",
        "paper:paper-dc03de1ebe17"
      ],
      "section_title": "Molecular Adaptations: Synaptic Plasticity, Transcriptional Cascades, and Epigenetic Mechanisms",
      "source_policy": {
        "mode": "public_source_pointer_with_short_context",
        "notes": [
          "Local review repositories are read-only inputs.",
          "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
        ],
        "source_commit_sha": "43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48",
        "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction"
      },
      "generation_status": "complete",
      "review_bundle_ref": "analysis_bundle:ab-d95cfb705572",
      "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction/blob/43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48/evidence/section_03_evidence.json",
      "commit_sha": "43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48",
      "created_by": "persona-jerome-lecoq-gbo-neuroscience",
      "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction"
    }