Gamma frequency range entrained by PV interneuron optogenetic activation across…

{
  "papers": [
    {
      "n": 0,
      "doi": "10.1038/nature08002",
      "value": "20-80 Hz",
      "method": "optogenetics + extracellular LFP",
      "metric": "Gamma frequency band amplified by FS cell activation",
      "n_analyzed": "",
      "ci_or_error": "",
      "text_access": "fulltext",
      "n_definition": "mice",
      "scope_region": "barrel cortex",
      "study_system": "mouse barrel cortex",
      "taxonomic_level": "broad category",
      "scope_population": "fast-spiking PV interneurons",
      "value_source_sentence": "Cortical gamma oscillations (20-80 Hz) predict increases in focused attention.",
      "experimental_conditions": "in vivo optogenetic activation of FS interneurons at 8-200 Hz"
    },
    {
      "n": 0,
      "doi": "10.1038/nature07991",
      "value": "30-80 Hz",
      "method": "optogenetics + LFP",
      "metric": "Gamma frequency band generated by PV cell activation",
      "n_analyzed": "",
      "ci_or_error": "",
      "text_access": "fulltext",
      "n_definition": "mice",
      "scope_region": "neocortex",
      "study_system": "mouse neocortex",
      "taxonomic_level": "broad category",
      "scope_population": "parvalbumin interneurons",
      "value_source_sentence": "Interneurons defined by the fast-spiking phenotype and expression of the calcium-binding protein parvalbumin have been suggested to be involved in gamma (30-80 Hz) oscillations.",
      "experimental_conditions": "in vivo optogenetic modulation of PV interneurons"
    },
    {
      "n": 0,
      "doi": "10.1016/j.neuron.2017.11.033",
      "value": "20-80 Hz",
      "method": "optogenetics + LFP recordings",
      "metric": "Gamma frequency band entrained by PV cell activation",
      "n_analyzed": "",
      "ci_or_error": "",
      "text_access": "fulltext",
      "n_definition": "mice",
      "scope_region": "primary visual cortex",
      "study_system": "mouse primary visual cortex",
      "taxonomic_level": "broad category",
      "scope_population": "parvalbumin interneurons",
      "value_source_sentence": "Rhythmic activation of SOM and PV cells in the local circuit entrains resonant activity in the narrow 5- to 30-Hz band and the wide 20- to 80-Hz band, respectively.",
      "experimental_conditions": "in vivo optogenetic activation of PV interneurons"
    },
    {
      "n": 0,
      "doi": "10.1038/s41467-019-13260-9",
      "value": "40 Hz",
      "method": "optogenetics + hippocampal LFP",
      "metric": "Optimal stimulation frequency for gamma restoration",
      "n_analyzed": "",
      "ci_or_error": "",
      "text_access": "fulltext",
      "n_definition": "J20-APP mice",
      "scope_region": "hippocampus",
      "study_system": "J20-APP AD mouse model hippocampus",
      "taxonomic_level": "broad category",
      "scope_population": "medial septal PV neurons",
      "value_source_sentence": "We show that optogenetic stimulation of parvalbumin neurons at 40 Hz (but not 80 Hz) restores hippocampal slow gamma oscillations amplitude.",
      "experimental_conditions": "optogenetic stimulation of medial septal PV neurons"
    }
  ],
  "comparison_id": "gamma-frequency-pv-optogenetic-entrainment",
  "comparison_name": "Gamma frequency range entrained by PV interneuron optogenetic activation across studies",
  "comparison_type": "convergent evidence",
  "what_it_reveals": "Multiple studies converge on 20-80 Hz as the gamma range entrained by PV interneuron activation, with 40 Hz being particularly effective for therapeutic gamma restoration",
  "homogeneity_check": {
    "caveats": [
      "Studies span different cortical regions (barrel cortex, V1, neocortex, hippocampus)",
      "AD model study targets medial septal PV neurons projecting to hippocampus, not local PV interneurons"
    ],
    "n_definition_uniform": "true",
    "scope_region_uniform": "false",
    "taxonomic_level_uniform": "true",
    "scope_population_uniform": "true"
  },
  "suggested_plot_type": "grouped bar"
}

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