Version history

{
  "kind": "infographic",
  "prompt": "Multiple studies converge on 20-80 Hz as the gamma range entrained by PV interneuron activation, with 40 Hz being particularly effective for therapeutic gamma restoration",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "n": 0,
        "doi": "10.1038/nature08002",
        "value": "20-80 Hz",
        "method": "optogenetics + extracellular LFP",
        "metric": "Gamma frequency band amplified by FS cell activation",
        "n_analyzed": "",
        "ci_or_error": "",
        "text_access": "fulltext",
        "n_definition": "mice",
        "scope_region": "barrel cortex",
        "study_system": "mouse barrel cortex",
        "taxonomic_level": "broad category",
        "scope_population": "fast-spiking PV interneurons",
        "value_source_sentence": "Cortical gamma oscillations (20-80 Hz) predict increases in focused attention.",
        "experimental_conditions": "in vivo optogenetic activation of FS interneurons at 8-200 Hz"
      },
      {
        "n": 0,
        "doi": "10.1038/nature07991",
        "value": "30-80 Hz",
        "method": "optogenetics + LFP",
        "metric": "Gamma frequency band generated by PV cell activation",
        "n_analyzed": "",
        "ci_or_error": "",
        "text_access": "fulltext",
        "n_definition": "mice",
        "scope_region": "neocortex",
        "study_system": "mouse neocortex",
        "taxonomic_level": "broad category",
        "scope_population": "parvalbumin interneurons",
        "value_source_sentence": "Interneurons defined by the fast-spiking phenotype and expression of the calcium-binding protein parvalbumin have been suggested to be involved in gamma (30-80 Hz) oscillations.",
        "experimental_conditions": "in vivo optogenetic modulation of PV interneurons"
      },
      {
        "n": 0,
        "doi": "10.1016/j.neuron.2017.11.033",
        "value": "20-80 Hz",
        "method": "optogenetics + LFP recordings",
        "metric": "Gamma frequency band entrained by PV cell activation",
        "n_analyzed": "",
        "ci_or_error": "",
        "text_access": "fulltext",
        "n_definition": "mice",
        "scope_region": "primary visual cortex",
        "study_system": "mouse primary visual cortex",
        "taxonomic_level": "broad category",
        "scope_population": "parvalbumin interneurons",
        "value_source_sentence": "Rhythmic activation of SOM and PV cells in the local circuit entrains resonant activity in the narrow 5- to 30-Hz band and the wide 20- to 80-Hz band, respectively.",
        "experimental_conditions": "in vivo optogenetic activation of PV interneurons"
      },
      {
        "n": 0,
        "doi": "10.1038/s41467-019-13260-9",
        "value": "40 Hz",
        "method": "optogenetics + hippocampal LFP",
        "metric": "Optimal stimulation frequency for gamma restoration",
        "n_analyzed": "",
        "ci_or_error": "",
        "text_access": "fulltext",
        "n_definition": "J20-APP mice",
        "scope_region": "hippocampus",
        "study_system": "J20-APP AD mouse model hippocampus",
        "taxonomic_level": "broad category",
        "scope_population": "medial septal PV neurons",
        "value_source_sentence": "We show that optogenetic stimulation of parvalbumin neurons at 40 Hz (but not 80 Hz) restores hippocampal slow gamma oscillations amplitude.",
        "experimental_conditions": "optogenetic stimulation of medial septal PV neurons"
      }
    ],
    "comparison_id": "gamma-frequency-pv-optogenetic-entrainment",
    "comparison_name": "Gamma frequency range entrained by PV interneuron optogenetic activation across studies",
    "comparison_type": "convergent evidence",
    "what_it_reveals": "Multiple studies converge on 20-80 Hz as the gamma range entrained by PV interneuron activation, with 40 Hz being particularly effective for therapeutic gamma restoration",
    "homogeneity_check": {
      "caveats": [
        "Studies span different cortical regions (barrel cortex, V1, neocortex, hippocampus)",
        "AD model study targets medial septal PV neurons projecting to hippocampus, not local PV interneurons"
      ],
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      "scope_region_uniform": "false",
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      "scope_population_uniform": "true"
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  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_10_evidence_package.json",
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  "review_repo": "ComputationalReviewPV",
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  "source_refs": [
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    "paper:paper-d5a7d63abc9a",
    "paper:3767f6c5-663b-42ad-bf68-d37f6f00b49d"
  ],
  "section_title": "Oscillations and Network Dynamics: Gamma, Ripples, and Synchrony",
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