SST-Mediated Dendritic Inhibition Gates Synaptic Plasticity Across Brain Regions

{
  "papers": [
    {
      "doi": "10.1038/nn.3024",
      "value": "SST provides tunable dendritic inhibition regulating input transformations",
      "method": "in vitro optogenetics and electrophysiology",
      "metric": "SST gating of dendritic integration",
      "cite_key": "LovettBarron2012",
      "condition": "SST activation/silencing",
      "study_system": "mouse hippocampus CA1",
      "value_source_sentence": "Regulation of neuronal input transformations by tunable dendritic inhibition"
    },
    {
      "doi": "10.1126/science.1247485",
      "value": "SST silencing impairs contextual fear memory formation",
      "method": "in vivo optogenetics, fear conditioning",
      "metric": "SST necessity for fear learning",
      "cite_key": "LovettBarron2014",
      "condition": "SST silencing during conditioning",
      "study_system": "mouse hippocampus CA1",
      "value_source_sentence": "Dendritic inhibition in the hippocampus supports fear learning"
    },
    {
      "doi": "10.1523/jneurosci.1369-21.2021",
      "value": "VIP activation via SST inhibition gates associative LTP",
      "method": "in vitro optogenetics",
      "metric": "VIP-SST disinhibition enables LTP",
      "cite_key": "CantoBustos2022",
      "condition": "VIP activation during LTP induction",
      "study_system": "mouse piriform cortex",
      "value_source_sentence": "LTP is gated by the inactivation SST or PV interneurons and by the activation of VIP interneurons"
    },
    {
      "doi": "10.1038/nature13664",
      "value": "Sensory-evoked dendritic plateau potentials drive LTP in vivo",
      "method": "in vivo electrophysiology",
      "metric": "Dendritic plateau potentials drive LTP",
      "cite_key": "Gambino2014",
      "condition": "sensory stimulation",
      "study_system": "mouse barrel cortex L2/3",
      "value_source_sentence": "Sensory-evoked LTP driven by dendritic plateau potentials in vivo"
    },
    {
      "doi": "10.1038/s41467-025-64859-0",
      "value": "OLM interneurons regulate place cell plasticity and remapping",
      "method": "in vivo electrophysiology and optogenetics",
      "metric": "OLM SST gating of place cell plasticity",
      "cite_key": "Udakis2025",
      "condition": "spatial exploration",
      "study_system": "mouse hippocampus CA1",
      "value_source_sentence": "OLM interneurons selectively target inhibition to the distal dendrites of CA1 pyramidal cells"
    }
  ],
  "comparison_id": "dendritic-inhibition-and-plasticity",
  "comparison_name": "SST-Mediated Dendritic Inhibition Gates Synaptic Plasticity Across Brain Regions",
  "comparison_type": "convergent evidence",
  "what_it_reveals": "Converging evidence across brain regions shows that SST-mediated dendritic inhibition is a gating mechanism for synaptic plasticity, with release from SST inhibition enabling dendritic calcium events required for LTP.",
  "homogeneity_check": {
    "caveats": [
      "Different brain regions (hippocampus, piriform, barrel cortex)",
      "Different plasticity paradigms",
      "Mix of in vitro and in vivo",
      "Different measures of plasticity"
    ],
    "comparable": false
  },
  "suggested_plot_type": "forest plot"
}

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  "paper:paper-7c1701946c71",
  "paper:paper-88ec00d4653f",
  "paper:paper-8bdf7e3be782",
  "paper:paper-e9f2f58c35e6"
]

{
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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
}