Version history

{
  "kind": "infographic",
  "prompt": "Converging evidence across brain regions shows that SST-mediated dendritic inhibition is a gating mechanism for synaptic plasticity, with release from SST inhibition enabling dendritic calcium events required for LTP.",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "doi": "10.1038/nn.3024",
        "value": "SST provides tunable dendritic inhibition regulating input transformations",
        "method": "in vitro optogenetics and electrophysiology",
        "metric": "SST gating of dendritic integration",
        "cite_key": "LovettBarron2012",
        "condition": "SST activation/silencing",
        "study_system": "mouse hippocampus CA1",
        "value_source_sentence": "Regulation of neuronal input transformations by tunable dendritic inhibition"
      },
      {
        "doi": "10.1126/science.1247485",
        "value": "SST silencing impairs contextual fear memory formation",
        "method": "in vivo optogenetics, fear conditioning",
        "metric": "SST necessity for fear learning",
        "cite_key": "LovettBarron2014",
        "condition": "SST silencing during conditioning",
        "study_system": "mouse hippocampus CA1",
        "value_source_sentence": "Dendritic inhibition in the hippocampus supports fear learning"
      },
      {
        "doi": "10.1523/jneurosci.1369-21.2021",
        "value": "VIP activation via SST inhibition gates associative LTP",
        "method": "in vitro optogenetics",
        "metric": "VIP-SST disinhibition enables LTP",
        "cite_key": "CantoBustos2022",
        "condition": "VIP activation during LTP induction",
        "study_system": "mouse piriform cortex",
        "value_source_sentence": "LTP is gated by the inactivation SST or PV interneurons and by the activation of VIP interneurons"
      },
      {
        "doi": "10.1038/nature13664",
        "value": "Sensory-evoked dendritic plateau potentials drive LTP in vivo",
        "method": "in vivo electrophysiology",
        "metric": "Dendritic plateau potentials drive LTP",
        "cite_key": "Gambino2014",
        "condition": "sensory stimulation",
        "study_system": "mouse barrel cortex L2/3",
        "value_source_sentence": "Sensory-evoked LTP driven by dendritic plateau potentials in vivo"
      },
      {
        "doi": "10.1038/s41467-025-64859-0",
        "value": "OLM interneurons regulate place cell plasticity and remapping",
        "method": "in vivo electrophysiology and optogenetics",
        "metric": "OLM SST gating of place cell plasticity",
        "cite_key": "Udakis2025",
        "condition": "spatial exploration",
        "study_system": "mouse hippocampus CA1",
        "value_source_sentence": "OLM interneurons selectively target inhibition to the distal dendrites of CA1 pyramidal cells"
      }
    ],
    "comparison_id": "dendritic-inhibition-and-plasticity",
    "comparison_name": "SST-Mediated Dendritic Inhibition Gates Synaptic Plasticity Across Brain Regions",
    "comparison_type": "convergent evidence",
    "what_it_reveals": "Converging evidence across brain regions shows that SST-mediated dendritic inhibition is a gating mechanism for synaptic plasticity, with release from SST inhibition enabling dendritic calcium events required for LTP.",
    "homogeneity_check": {
      "caveats": [
        "Different brain regions (hippocampus, piriform, barrel cortex)",
        "Different plasticity paradigms",
        "Mix of in vitro and in vivo",
        "Different measures of plasticity"
      ],
      "comparable": false
    },
    "suggested_plot_type": "forest plot"
  },
  "section_id": "section_07_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_07_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewsst-07",
  "review_repo": "ComputationalReviewSST",
  "section_ref": "wiki_page:computationalreviewsst-07",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-28660a26542f",
    "paper:paper-7c1701946c71",
    "paper:paper-88ec00d4653f",
    "paper:paper-8bdf7e3be782",
    "paper:paper-e9f2f58c35e6"
  ],
  "section_title": "Circuit Motifs and Dendritic Computation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
  },
  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-8466d095488a",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_07_evidence_package.json",
  "commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
}