PV interneuron density/expression changes across psychiatric disorder meta-anal…

{
  "papers": [
    {
      "n": 549,
      "doi": "10.1007/s00702-019-02080-2",
      "value": "-0.27",
      "method": "Meta-analysis of postmortem studies",
      "metric": "Hedges' g for PV cell density reduction in schizophrenia",
      "n_analyzed": 549,
      "ci_or_error": "p = 0.03",
      "text_access": "fulltext",
      "n_definition": "Total subjects across studies (n=274 SCZ, n=275 controls)",
      "scope_region": "Prefrontal cortex",
      "study_system": "Postmortem brain, schizophrenia",
      "taxonomic_level": "PV+ cell type",
      "scope_population": "All PV+ neurons in region",
      "value_source_sentence": "The results suggest that parvalbumin interneurons are reduced in density in the frontal cortex of patients with schizophrenia (Hedges' g = - 0.27; p = 0.03).",
      "experimental_conditions": "Prefrontal cortex, PV immunohistochemistry"
    },
    {
      "n": 0,
      "doi": "10.3389/fphar.2021.689473",
      "value": "Meta-analytical evidence positive",
      "method": "Meta-analysis and systematic review",
      "metric": "Evidence of PV loss in bipolar disorder",
      "n_analyzed": 0,
      "ci_or_error": null,
      "text_access": "fulltext",
      "n_definition": "Not specified in abstract",
      "scope_region": "Multiple brain regions",
      "study_system": "Postmortem brain, bipolar disorder",
      "taxonomic_level": "PV+ cell type",
      "scope_population": "All PV+ neurons",
      "value_source_sentence": "We hereby report meta-analytical evidence of parvalbumin interneurons loss or dysfunction in the brain of patients with Bipolar Affective Disorder.",
      "experimental_conditions": "Multiple brain regions"
    }
  ],
  "comparison_id": "pv-density-meta-analyses-comparison",
  "comparison_name": "PV interneuron density/expression changes across psychiatric disorder meta-analyses",
  "comparison_type": "convergent evidence",
  "what_it_reveals": "PV deficits are shared across psychiatric disorders but with variable effect sizes and significance, suggesting a transdiagnostic vulnerability.",
  "homogeneity_check": {
    "caveats": [
      "Schizophrenia meta-analysis focused on prefrontal cortex while BPAD review covered multiple regions",
      "Different outcome measures: cell density vs mRNA vs combined"
    ],
    "n_definition_uniform": "false",
    "scope_region_uniform": "false",
    "taxonomic_level_uniform": "true",
    "scope_population_uniform": "true"
  },
  "suggested_plot_type": "forest plot"
}

[
  "paper:paper-7c8238b53305",
  "paper:paper-8a23937e9dab"
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}