Version history

{
  "kind": "infographic",
  "prompt": "PV deficits are shared across psychiatric disorders but with variable effect sizes and significance, suggesting a transdiagnostic vulnerability.",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "n": 549,
        "doi": "10.1007/s00702-019-02080-2",
        "value": "-0.27",
        "method": "Meta-analysis of postmortem studies",
        "metric": "Hedges' g for PV cell density reduction in schizophrenia",
        "n_analyzed": 549,
        "ci_or_error": "p = 0.03",
        "text_access": "fulltext",
        "n_definition": "Total subjects across studies (n=274 SCZ, n=275 controls)",
        "scope_region": "Prefrontal cortex",
        "study_system": "Postmortem brain, schizophrenia",
        "taxonomic_level": "PV+ cell type",
        "scope_population": "All PV+ neurons in region",
        "value_source_sentence": "The results suggest that parvalbumin interneurons are reduced in density in the frontal cortex of patients with schizophrenia (Hedges' g = - 0.27; p = 0.03).",
        "experimental_conditions": "Prefrontal cortex, PV immunohistochemistry"
      },
      {
        "n": 0,
        "doi": "10.3389/fphar.2021.689473",
        "value": "Meta-analytical evidence positive",
        "method": "Meta-analysis and systematic review",
        "metric": "Evidence of PV loss in bipolar disorder",
        "n_analyzed": 0,
        "ci_or_error": null,
        "text_access": "fulltext",
        "n_definition": "Not specified in abstract",
        "scope_region": "Multiple brain regions",
        "study_system": "Postmortem brain, bipolar disorder",
        "taxonomic_level": "PV+ cell type",
        "scope_population": "All PV+ neurons",
        "value_source_sentence": "We hereby report meta-analytical evidence of parvalbumin interneurons loss or dysfunction in the brain of patients with Bipolar Affective Disorder.",
        "experimental_conditions": "Multiple brain regions"
      }
    ],
    "comparison_id": "pv-density-meta-analyses-comparison",
    "comparison_name": "PV interneuron density/expression changes across psychiatric disorder meta-analyses",
    "comparison_type": "convergent evidence",
    "what_it_reveals": "PV deficits are shared across psychiatric disorders but with variable effect sizes and significance, suggesting a transdiagnostic vulnerability.",
    "homogeneity_check": {
      "caveats": [
        "Schizophrenia meta-analysis focused on prefrontal cortex while BPAD review covered multiple regions",
        "Different outcome measures: cell density vs mRNA vs combined"
      ],
      "n_definition_uniform": "false",
      "scope_region_uniform": "false",
      "taxonomic_level_uniform": "true",
      "scope_population_uniform": "true"
    },
    "suggested_plot_type": "forest plot"
  },
  "section_id": "section_13_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_13_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewpv-13",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-13",
  "source_path": "evidence/section_13_evidence_package.json",
  "source_refs": [
    "paper:paper-7c8238b53305",
    "paper:paper-8a23937e9dab"
  ],
  "section_title": "Cross-Cluster Synthesis: What Replicates, What Is Contested, What Is Untested",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_13_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}