Version history

{
  "kind": "infographic",
  "prompt": "GAD67 reduction in PV neurons is remarkably consistent (~50% of PV cells affected) across studies and cortical regions, supporting a core pathological feature of schizophrenia",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "n": 15,
        "doi": "10.1523/jneurosci.23-15-06315.2003",
        "value": "55%",
        "method": "dual-label in situ hybridization",
        "metric": "Percentage of PV neurons with detectable GAD67 mRNA",
        "n_analyzed": 15,
        "ci_or_error": null,
        "text_access": "abstract_only",
        "n_definition": "subject pairs (schizophrenia vs matched control)",
        "scope_region": "prefrontal cortex area 9",
        "study_system": "human postmortem PFC area 9",
        "taxonomic_level": "single cell type (PV neurons)",
        "scope_population": "PV mRNA-positive neurons",
        "value_source_sentence": "In subjects with schizophrenia only 55% of PV mRNA-positive neurons had detectable levels of GAD67 mRNA.",
        "experimental_conditions": "matched pairs schizophrenia vs control"
      },
      {
        "n": 12,
        "doi": "10.1176/appi.ajp.2007.07081223",
        "value": "largest reductions among GABA transcripts examined",
        "method": "real-time quantitative PCR",
        "metric": "Relative reduction of PV mRNA across cortical areas",
        "n_analyzed": 12,
        "ci_or_error": null,
        "text_access": "fulltext",
        "n_definition": "subject pairs",
        "scope_region": "4 cortical areas (DLPFC, ACC, motor, visual)",
        "study_system": "human postmortem 4 cortical areas (DLPFC, ACC, M1, V1)",
        "taxonomic_level": "transcript level (PV, SST, GAD67, GAT-1, CR)",
        "scope_population": "all neurons in region",
        "value_source_sentence": "The largest reductions were detected for mRNA encoding somatostatin and parvalbumin, followed by moderate decreases in mRNA expression for the 67-kilodalton isoform of glutamic acid decarboxylase.",
        "experimental_conditions": "schizophrenia vs matched normal comparison subjects"
      },
      {
        "n": 0,
        "doi": "10.1016/j.tins.2011.10.004",
        "value": "~50%",
        "method": "review synthesis of in situ hybridization data",
        "metric": "Proportion of PV neurons with lower GAD67 mRNA",
        "n_analyzed": 0,
        "ci_or_error": null,
        "text_access": "fulltext",
        "n_definition": "review summarizing multiple cohorts",
        "scope_region": "DLPFC layer 3",
        "study_system": "human postmortem DLPFC",
        "taxonomic_level": "single cell type (PV neurons)",
        "scope_population": "PV-positive neurons",
        "value_source_sentence": "In the DLPFC, GAD67 mRNA levels are lower in schizophrenia, and this deficit appears to be present in ~50% of PV neurons.",
        "experimental_conditions": "schizophrenia vs control"
      }
    ],
    "comparison_id": "gad67-reduction-across-cortical-regions-schizophrenia",
    "comparison_name": "GAD67/PV mRNA reductions across cortical regions in schizophrenia",
    "comparison_type": "convergent evidence",
    "what_it_reveals": "GAD67 reduction in PV neurons is remarkably consistent (~50% of PV cells affected) across studies and cortical regions, supporting a core pathological feature of schizophrenia",
    "homogeneity_check": {
      "caveats": [
        "One paper examines 4 cortical areas while others focus on DLPFC only",
        "One entry is from a review synthesis rather than original data",
        "n_definition varies: some count subject pairs, one is a review"
      ],
      "n_definition_uniform": "false",
      "scope_region_uniform": "false",
      "taxonomic_level_uniform": "true",
      "scope_population_uniform": "true"
    },
    "suggested_plot_type": "grouped bar"
  },
  "section_id": "section_11_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_11_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewpv-11",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-11",
  "source_path": "evidence/section_11_evidence_package.json",
  "source_refs": [
    "paper:paper-6d36973b50ab",
    "paper:paper-9febfa10db1a",
    "paper:paper-fe0468c6576e"
  ],
  "section_title": "Species Translation, Human Data, and Disease Models",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_11_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}