Martinotti Cell Molecular Co-expression Profiles Across Cortical Layers

{
  "papers": [
    {
      "doi": "10.1113/jphysiol.2004.073353",
      "value": "100% positive",
      "method": "single-cell RT-PCR after biocytin filling",
      "metric": "SOM expression in Martinotti cells",
      "cite_key": "Wang2004",
      "condition": "somatosensory cortex, P13-16, n=63",
      "study_system": "rat",
      "value_source_sentence": "Single-cell multiplex RT-PCR performed on 63 MCs located throughout layers II–VI, revealed that all MCs were somatostatin (SOM) positive, and negative for parvalbumin (PV) as well as vasoactive intestinal peptide (VIP)."
    },
    {
      "doi": "10.1113/jphysiol.2004.073353",
      "value": "0% (all negative)",
      "method": "single-cell RT-PCR after biocytin filling",
      "metric": "PV expression in Martinotti cells",
      "cite_key": "Wang2004",
      "condition": "somatosensory cortex, P13-16, n=63",
      "study_system": "rat",
      "value_source_sentence": "all MCs were somatostatin (SOM) positive, and negative for parvalbumin (PV) as well as vasoactive intestinal peptide (VIP)."
    },
    {
      "doi": "10.1113/jphysiol.2004.073353",
      "value": "variable co-expression with layer-specific trends",
      "method": "single-cell RT-PCR after biocytin filling",
      "metric": "CB, CR, NPY, CCK co-expression with SOM",
      "cite_key": "Wang2004",
      "condition": "somatosensory cortex, P13-16, n=63",
      "study_system": "rat",
      "value_source_sentence": "Calbindin (CB), calretinin (CR), neuropeptide Y (NPY) and cholecystokinin (CCK) were co-expressed with SOM in some MCs. Some layer-specific trends seem to exist."
    }
  ],
  "n_analyzed": "63",
  "n_definition": "individual biocytin-filled neurons tested by single-cell RT-PCR",
  "scope_region": "rat somatosensory cortex",
  "comparison_id": "mc-molecular-profile-by-layer",
  "comparison_name": "Martinotti Cell Molecular Co-expression Profiles Across Cortical Layers",
  "comparison_type": "convergent evidence",
  "taxonomic_level": "molecular co-expression profile",
  "what_it_reveals": "All biocytin-filled Martinotti cells across layers II-VI are SOM+/PV-/VIP-, but co-expression of calbindin, calretinin, NPY, and CCK varies, suggesting molecular heterogeneity within the Martinotti cell population.",
  "scope_population": "morphologically-defined Martinotti cells (biocytin-filled)",
  "homogeneity_check": {
    "caveats": [
      "All data from single study (Wang et al. 2004) — cross-lab replication needed",
      "Juvenile rat tissue (P13-16) — co-expression patterns may change with maturation"
    ],
    "metric_consistent": true,
    "scope_region_uniform": true,
    "taxonomic_level_uniform": true,
    "scope_population_uniform": true
  },
  "suggested_plot_type": "heatmap"
}

[
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]

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