Version history

{
  "kind": "infographic",
  "prompt": "All biocytin-filled Martinotti cells across layers II-VI are SOM+/PV-/VIP-, but co-expression of calbindin, calretinin, NPY, and CCK varies, suggesting molecular heterogeneity within the Martinotti cell population.",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "doi": "10.1113/jphysiol.2004.073353",
        "value": "100% positive",
        "method": "single-cell RT-PCR after biocytin filling",
        "metric": "SOM expression in Martinotti cells",
        "cite_key": "Wang2004",
        "condition": "somatosensory cortex, P13-16, n=63",
        "study_system": "rat",
        "value_source_sentence": "Single-cell multiplex RT-PCR performed on 63 MCs located throughout layers II–VI, revealed that all MCs were somatostatin (SOM) positive, and negative for parvalbumin (PV) as well as vasoactive intestinal peptide (VIP)."
      },
      {
        "doi": "10.1113/jphysiol.2004.073353",
        "value": "0% (all negative)",
        "method": "single-cell RT-PCR after biocytin filling",
        "metric": "PV expression in Martinotti cells",
        "cite_key": "Wang2004",
        "condition": "somatosensory cortex, P13-16, n=63",
        "study_system": "rat",
        "value_source_sentence": "all MCs were somatostatin (SOM) positive, and negative for parvalbumin (PV) as well as vasoactive intestinal peptide (VIP)."
      },
      {
        "doi": "10.1113/jphysiol.2004.073353",
        "value": "variable co-expression with layer-specific trends",
        "method": "single-cell RT-PCR after biocytin filling",
        "metric": "CB, CR, NPY, CCK co-expression with SOM",
        "cite_key": "Wang2004",
        "condition": "somatosensory cortex, P13-16, n=63",
        "study_system": "rat",
        "value_source_sentence": "Calbindin (CB), calretinin (CR), neuropeptide Y (NPY) and cholecystokinin (CCK) were co-expressed with SOM in some MCs. Some layer-specific trends seem to exist."
      }
    ],
    "n_analyzed": "63",
    "n_definition": "individual biocytin-filled neurons tested by single-cell RT-PCR",
    "scope_region": "rat somatosensory cortex",
    "comparison_id": "mc-molecular-profile-by-layer",
    "comparison_name": "Martinotti Cell Molecular Co-expression Profiles Across Cortical Layers",
    "comparison_type": "convergent evidence",
    "taxonomic_level": "molecular co-expression profile",
    "what_it_reveals": "All biocytin-filled Martinotti cells across layers II-VI are SOM+/PV-/VIP-, but co-expression of calbindin, calretinin, NPY, and CCK varies, suggesting molecular heterogeneity within the Martinotti cell population.",
    "scope_population": "morphologically-defined Martinotti cells (biocytin-filled)",
    "homogeneity_check": {
      "caveats": [
        "All data from single study (Wang et al. 2004) — cross-lab replication needed",
        "Juvenile rat tissue (P13-16) — co-expression patterns may change with maturation"
      ],
      "metric_consistent": true,
      "scope_region_uniform": true,
      "taxonomic_level_uniform": true,
      "scope_population_uniform": true
    },
    "suggested_plot_type": "heatmap"
  },
  "section_id": "section_04_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_04_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewsst-04",
  "review_repo": "ComputationalReviewSST",
  "section_ref": "wiki_page:computationalreviewsst-04",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:paper-0cee20f3440c"
  ],
  "section_title": "Morphological Diversity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
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  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-8466d095488a",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_04_evidence_package.json",
  "commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
}