Mechanisms Contributing to Surround Suppression in Visual Cortex

{
  "papers": [
    {
      "doi": "10.1038/nature11526",
      "value": "SST silencing abolishes surround suppression",
      "method": "in vivo optogenetics",
      "metric": "SST contribution to surround suppression",
      "cite_key": "Adesnik2012",
      "condition": "SST silencing",
      "study_system": "mouse V1",
      "value_source_sentence": "Whether cortical circuits contribute to surround suppression or whether the phenomenon is entirely inherited from upstream processing stages has been debated"
    },
    {
      "doi": "10.1038/s41467-018-04500-5",
      "value": "V2 feedback inactivation reduces surround suppression",
      "method": "V2 cooling and electrophysiology",
      "metric": "Feedback contribution to surround suppression",
      "cite_key": "Nurminen2018",
      "condition": "V2 feedback inactivation",
      "study_system": "macaque V1-V2",
      "value_source_sentence": "Feedback has been implicated in attention, expectation, and surround modulation"
    },
    {
      "doi": "10.1016/j.celrep.2025.115954",
      "value": "SST role depends on behavioral state and stimulus strength",
      "method": "in vivo optogenetics",
      "metric": "State-dependence of SST role",
      "cite_key": "Cammarata2025",
      "condition": "varying behavioral states",
      "study_system": "mouse V1",
      "value_source_sentence": "Behavioral state and stimulus strength regulate the role of somatostatin interneurons"
    },
    {
      "doi": "10.1016/j.neuron.2019.10.027",
      "value": "Retino-colliculo-pulvinar pathway activates SST neurons for surround enhancement",
      "method": "in vivo optogenetics and tracing",
      "metric": "Subcortical contribution via pulvinar",
      "cite_key": "Fang2020",
      "condition": "pulvinar pathway manipulation",
      "study_system": "mouse V1",
      "value_source_sentence": "A Differential Circuit via Retino-Colliculo-Pulvinar Pathway Enhances Feature Selectivity"
    },
    {
      "doi": "10.1016/j.neuron.2025.12.021",
      "value": "Feature-tuned synaptic inputs to SST drive context-dependent surround suppression",
      "method": "in vivo electrophysiology and imaging",
      "metric": "Feature-tuned SST inputs for context-dependent suppression",
      "cite_key": "Hendricks2026",
      "condition": "feature-specific stimulation",
      "study_system": "mouse V1",
      "value_source_sentence": "Mapping neural computation onto the functional microarchitecture of sensory circuits is essential for understanding how brain circuits transform input signals"
    }
  ],
  "comparison_id": "surround-suppression-mechanisms",
  "comparison_name": "Mechanisms Contributing to Surround Suppression in Visual Cortex",
  "comparison_type": "convergent evidence",
  "what_it_reveals": "Multiple circuit mechanisms contribute to surround suppression, challenging the view that SST lateral inhibition is the sole cortical mechanism.",
  "homogeneity_check": {
    "caveats": [
      "Different species (mouse vs macaque)",
      "Different manipulation methods",
      "Different definitions of surround suppression index"
    ],
    "comparable": false
  },
  "suggested_plot_type": "heatmap"
}

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  "paper:paper-552581d26fa1",
  "paper:paper-6922f4d24e18",
  "paper:paper-7fa8ffc9f200",
  "paper:paper-e7df69a6efbc"
]

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    "Local review repositories are read-only inputs.",
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