Version history

{
  "kind": "infographic",
  "prompt": "Multiple circuit mechanisms contribute to surround suppression, challenging the view that SST lateral inhibition is the sole cortical mechanism.",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "doi": "10.1038/nature11526",
        "value": "SST silencing abolishes surround suppression",
        "method": "in vivo optogenetics",
        "metric": "SST contribution to surround suppression",
        "cite_key": "Adesnik2012",
        "condition": "SST silencing",
        "study_system": "mouse V1",
        "value_source_sentence": "Whether cortical circuits contribute to surround suppression or whether the phenomenon is entirely inherited from upstream processing stages has been debated"
      },
      {
        "doi": "10.1038/s41467-018-04500-5",
        "value": "V2 feedback inactivation reduces surround suppression",
        "method": "V2 cooling and electrophysiology",
        "metric": "Feedback contribution to surround suppression",
        "cite_key": "Nurminen2018",
        "condition": "V2 feedback inactivation",
        "study_system": "macaque V1-V2",
        "value_source_sentence": "Feedback has been implicated in attention, expectation, and surround modulation"
      },
      {
        "doi": "10.1016/j.celrep.2025.115954",
        "value": "SST role depends on behavioral state and stimulus strength",
        "method": "in vivo optogenetics",
        "metric": "State-dependence of SST role",
        "cite_key": "Cammarata2025",
        "condition": "varying behavioral states",
        "study_system": "mouse V1",
        "value_source_sentence": "Behavioral state and stimulus strength regulate the role of somatostatin interneurons"
      },
      {
        "doi": "10.1016/j.neuron.2019.10.027",
        "value": "Retino-colliculo-pulvinar pathway activates SST neurons for surround enhancement",
        "method": "in vivo optogenetics and tracing",
        "metric": "Subcortical contribution via pulvinar",
        "cite_key": "Fang2020",
        "condition": "pulvinar pathway manipulation",
        "study_system": "mouse V1",
        "value_source_sentence": "A Differential Circuit via Retino-Colliculo-Pulvinar Pathway Enhances Feature Selectivity"
      },
      {
        "doi": "10.1016/j.neuron.2025.12.021",
        "value": "Feature-tuned synaptic inputs to SST drive context-dependent surround suppression",
        "method": "in vivo electrophysiology and imaging",
        "metric": "Feature-tuned SST inputs for context-dependent suppression",
        "cite_key": "Hendricks2026",
        "condition": "feature-specific stimulation",
        "study_system": "mouse V1",
        "value_source_sentence": "Mapping neural computation onto the functional microarchitecture of sensory circuits is essential for understanding how brain circuits transform input signals"
      }
    ],
    "comparison_id": "surround-suppression-mechanisms",
    "comparison_name": "Mechanisms Contributing to Surround Suppression in Visual Cortex",
    "comparison_type": "convergent evidence",
    "what_it_reveals": "Multiple circuit mechanisms contribute to surround suppression, challenging the view that SST lateral inhibition is the sole cortical mechanism.",
    "homogeneity_check": {
      "caveats": [
        "Different species (mouse vs macaque)",
        "Different manipulation methods",
        "Different definitions of surround suppression index"
      ],
      "comparable": false
    },
    "suggested_plot_type": "heatmap"
  },
  "section_id": "section_07_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_07_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewsst-07",
  "review_repo": "ComputationalReviewSST",
  "section_ref": "wiki_page:computationalreviewsst-07",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-48f7973b62f1",
    "paper:paper-552581d26fa1",
    "paper:paper-6922f4d24e18",
    "paper:paper-7fa8ffc9f200",
    "paper:paper-e7df69a6efbc"
  ],
  "section_title": "Circuit Motifs and Dendritic Computation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
  },
  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-8466d095488a",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_07_evidence_package.json",
  "commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
}