Cross-Species Conservation of SST Neuron Subtypes in Cortex

While major SST neuron classes are conserved across mammals, human/primate cortex shows expanded diversity and species-specific molecular features. This figure quantifies the degree of conservation and highlights human-specific SST populations that may limit the translational value of mouse models.

{
  "papers": [
    {
      "doi": "10.1126/science.abo7257",
      "value": "Most subtypes conserved but human-specific SST-TH switching detected in >600,000 nuclei from 4 primate species",
      "method": "snRNA-seq",
      "metric": "SST subtype conservation across primates",
      "cite_key": "Ma2022",
      "condition": "adult healthy tissue",
      "study_system": "human, chimpanzee, macaque, marmoset dlPFC",
      "value_source_sentence": "While most transcriptomically-defined cell subtypes are conserved, we detected several only in some species and substantial species-specific molecular differences across homologous neuronal, glial and non-neural subtypes."
    },
    {
      "doi": "10.1038/s41467-025-67270-x",
      "value": "Spatial transcriptomics and differential gene expression (DGE) analyses reveal early KCC2-expressing INs localize predominantly to layer 5, express somatostatin, and show upregulation of synaptogenic ",
      "method": "transcriptomics",
      "metric": "SST subtype conservation",
      "cite_key": "Szrinivasan2025",
      "condition": "cross-species comparison",
      "study_system": "cross-species cortex",
      "value_source_sentence": "Spatial transcriptomics and differential gene expression (DGE) analyses reveal early KCC2-expressing INs localize predominantly to layer 5, express somatostatin, and show upregulation of synaptogenic genes, consistent with the recorded elevated synaptic activity."
    }
  ],
  "n_analyzed": ">600,000 (Ma et al.)",
  "n_definition": "single nuclei profiled",
  "scope_region": "dorsolateral prefrontal cortex and motor cortex",
  "comparison_id": "cross-species-sst-conservation",
  "comparison_name": "Cross-Species Conservation of SST Neuron Subtypes in Cortex",
  "comparison_type": "convergent evidence",
  "taxonomic_level": "transcriptomic subtype",
  "what_it_reveals": "While major SST neuron classes are conserved across mammals, human/primate cortex shows expanded diversity and species-specific molecular features. This figure quantifies the degree of conservation and highlights human-specific SST populations that may limit the translational value of mouse models.",
  "scope_population": "SST-expressing GABAergic interneurons",
  "homogeneity_check": {
    "caveats": [
      "Different brain regions sampled across studies",
      "Different cell clustering algorithms and resolution parameters",
      "Varying depth of sequencing coverage affects subtype detection"
    ],
    "comparable": true
  },
  "suggested_plot_type": "grouped bar"
}

[
  "paper:paper-9e019e94edbb",
  "paper:paper-e2d1deb9eeb2"
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
}