Version history

{
  "kind": "infographic",
  "prompt": "While major SST neuron classes are conserved across mammals, human/primate cortex shows expanded diversity and species-specific molecular features. This figure quantifies the degree of conservation and highlights human-specific SST populations that may limit the translational value of mouse models.",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "doi": "10.1126/science.abo7257",
        "value": "Most subtypes conserved but human-specific SST-TH switching detected in >600,000 nuclei from 4 primate species",
        "method": "snRNA-seq",
        "metric": "SST subtype conservation across primates",
        "cite_key": "Ma2022",
        "condition": "adult healthy tissue",
        "study_system": "human, chimpanzee, macaque, marmoset dlPFC",
        "value_source_sentence": "While most transcriptomically-defined cell subtypes are conserved, we detected several only in some species and substantial species-specific molecular differences across homologous neuronal, glial and non-neural subtypes."
      },
      {
        "doi": "10.1038/s41467-025-67270-x",
        "value": "Spatial transcriptomics and differential gene expression (DGE) analyses reveal early KCC2-expressing INs localize predominantly to layer 5, express somatostatin, and show upregulation of synaptogenic ",
        "method": "transcriptomics",
        "metric": "SST subtype conservation",
        "cite_key": "Szrinivasan2025",
        "condition": "cross-species comparison",
        "study_system": "cross-species cortex",
        "value_source_sentence": "Spatial transcriptomics and differential gene expression (DGE) analyses reveal early KCC2-expressing INs localize predominantly to layer 5, express somatostatin, and show upregulation of synaptogenic genes, consistent with the recorded elevated synaptic activity."
      }
    ],
    "n_analyzed": ">600,000 (Ma et al.)",
    "n_definition": "single nuclei profiled",
    "scope_region": "dorsolateral prefrontal cortex and motor cortex",
    "comparison_id": "cross-species-sst-conservation",
    "comparison_name": "Cross-Species Conservation of SST Neuron Subtypes in Cortex",
    "comparison_type": "convergent evidence",
    "taxonomic_level": "transcriptomic subtype",
    "what_it_reveals": "While major SST neuron classes are conserved across mammals, human/primate cortex shows expanded diversity and species-specific molecular features. This figure quantifies the degree of conservation and highlights human-specific SST populations that may limit the translational value of mouse models.",
    "scope_population": "SST-expressing GABAergic interneurons",
    "homogeneity_check": {
      "caveats": [
        "Different brain regions sampled across studies",
        "Different cell clustering algorithms and resolution parameters",
        "Varying depth of sequencing coverage affects subtype detection"
      ],
      "comparable": true
    },
    "suggested_plot_type": "grouped bar"
  },
  "section_id": "section_11_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_11_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewsst-11",
  "review_repo": "ComputationalReviewSST",
  "section_ref": "wiki_page:computationalreviewsst-11",
  "source_path": "evidence/section_11_evidence_package.json",
  "source_refs": [
    "paper:paper-9e019e94edbb",
    "paper:paper-e2d1deb9eeb2"
  ],
  "section_title": "Species Translation and Human Relevance",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
  },
  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-8466d095488a",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_11_evidence_package.json",
  "commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
}