Version history

{
  "kind": "infographic",
  "prompt": "Hippocampal SST subtypes have fundamentally different connectivity: O-LM cells target distal dendrites in SLM, bistratified cells target proximal dendrites in SR/SO, and Sst;;Tac1 bistratified cells specifically target fast-spiking interneurons. These connectivity differences predict distinct circuit functions that cannot be captured by bulk SST manipulation.",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "doi": "10.1073/pnas.2306382121",
        "value": "Sst;;Tac1 bistratified: 85% IPSCs in pyramidal cells, selectively interrupt FS-INs; OLM (Ndnf;;Nkx2-1): 0% FS-IN interruption",
        "method": "paired recordings + optogenetics",
        "metric": "Postsynaptic target selectivity",
        "cite_key": "Chamberland2024",
        "condition": "in vitro CA1",
        "study_system": "mouse",
        "value_source_sentence": "The summed subgroup events represented 85% of the IPSC in CA1-PYRs directly recorded upon by optogenetic stimulation of the general Sst-IN population; for FS-INs, the corresponding percentage was 75%. We found that photostimulation of subgroups failed to induce the interruption of firing in the case of Ndnf;;Nkx2-1-INs (0% likelihood, n = 5), Chrna2-INs (0.9 ± 0.8% likelihood, n = 11)."
      },
      {
        "doi": "10.3389/fnsyn.2014.00023",
        "value": "O-LM: stratum lacunosum-moleculare (distal); Bistratified: strata radiatum and oriens (proximal)",
        "method": "morphological + computational",
        "metric": "Dendritic domain targeting",
        "cite_key": "MAller2014",
        "condition": "CA1 circuit",
        "study_system": "rat/mouse",
        "value_source_sentence": "Dendritic inhibition mediated by O-LM and bistratified interneurons in the hippocampus."
      },
      {
        "doi": "10.1016/s0306-4522(98)00302-9",
        "value": "SST+ axon terminals preferentially contact dendrites of pyramidal cells",
        "method": "electron microscopy",
        "metric": "Electron microscopy targets",
        "cite_key": "Katona1999",
        "condition": "CA1",
        "study_system": "rat",
        "value_source_sentence": "Postsynaptic targets of somatostatin-immunoreactive interneurons in the rat hippocampus."
      },
      {
        "doi": "10.1093/cercor/bhaa359",
        "value": "O-LM: <20% responsive; PV/VIP: >70% responsive",
        "method": "optogenetics + patch clamp",
        "metric": "Input responsiveness to alvear pathway",
        "cite_key": "Bell2021",
        "condition": "in vitro CA1",
        "study_system": "mouse",
        "value_source_sentence": "alvear excitatory synaptic responses were observed in greater than 70% of PV and VIP interneurons and less than 20% of O-LM cells."
      }
    ],
    "comparison_id": "sst-subtype-connectivity-comparison",
    "comparison_name": "Connectivity Patterns of Hippocampal SST Interneuron Subtypes",
    "comparison_type": "convergent evidence",
    "what_it_reveals": "Hippocampal SST subtypes have fundamentally different connectivity: O-LM cells target distal dendrites in SLM, bistratified cells target proximal dendrites in SR/SO, and Sst;;Tac1 bistratified cells specifically target fast-spiking interneurons. These connectivity differences predict distinct circuit functions that cannot be captured by bulk SST manipulation.",
    "homogeneity_check": {
      "caveats": "Mixed species (rat and mouse), different methods (EM, paired recordings, optogenetics). Core finding of distinct dendritic targeting domains is consistent across approaches.",
      "comparable": true,
      "n_definition": "individual cells or connections",
      "scope_region": "CA1",
      "taxonomic_level": "subtype-specific",
      "scope_population": "SST+ interneuron subtypes"
    },
    "suggested_plot_type": "heatmap"
  },
  "section_id": "section_09_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_09_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewsst-09",
  "review_repo": "ComputationalReviewSST",
  "section_ref": "wiki_page:computationalreviewsst-09",
  "source_path": "evidence/section_09_evidence_package.json",
  "source_refs": [
    "paper:paper-bec9f93b6eaf",
    "paper:paper-de14fd3d41ad",
    "paper:paper-cf171ce288a9",
    "paper:paper-ffdd928a6c0b"
  ],
  "section_title": "Hippocampal SST Interneurons",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
  },
  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-8466d095488a",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_09_evidence_package.json",
  "commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
}