BF Cell Types and Their Cortical/Subcortical Effects

{
  "title": "BF Cell Types and Their Cortical/Subcortical Effects",
  "papers": [
    {
      "n": 36,
      "doi": "10.1523/JNEUROSCI.3979-05.2006",
      "value": "34/36 (94%) released glutamate; 6/6 co-released ACh",
      "method": "whole-cell recording + myoball assay",
      "metric": "co-transmitter release from BF cholinergic neurons",
      "n_analyzed": 36,
      "CI_or_error": "atropine enhanced EPSCs by 25±6%; neostigmine reduced EPSCs by 37±6%",
      "text_access": "fulltext",
      "n_definition": "single BF neurons in microisland culture",
      "scope_region": "basal forebrain (cultured)",
      "study_system": "rat, microisland cultures",
      "taxonomic_level": "species (rat)",
      "scope_population": "individual cholinergic BF neurons",
      "value_source_sentence": "In 34 of 36 cells tested, a somatically generated action potential was followed by a short-latency EPSC that was blocked by 1 mM kynurenic acid, showing that they released glutamate.",
      "experimental_conditions": "single neuron autaptic connections"
    },
    {
      "n": null,
      "doi": "10.1038/s42003-024-07318-8",
      "value": "frequency-specific modulation of auditory cortex",
      "method": "optogenetics + cortical recording",
      "metric": "BF GABAergic effect on cortex",
      "n_analyzed": null,
      "CI_or_error": null,
      "text_access": "abstract_only",
      "n_definition": "mice",
      "scope_region": "auditory cortex",
      "study_system": "mice, optogenetics",
      "taxonomic_level": "species (mouse)",
      "scope_population": "cortical neurons",
      "value_source_sentence": "GABAergic neurons in basal forebrain exert frequency-specific modulation on auditory cortex and enhance auditory attention.",
      "experimental_conditions": "BF GABAergic neuron stimulation"
    },
    {
      "n": null,
      "doi": "10.1016/j.neuron.2024.01.017",
      "value": "cholinergic vs non-cholinergic BF neurons modulate distinct large-scale networks",
      "method": "optogenetic fMRI",
      "metric": "BF cell-type network modulation",
      "n_analyzed": null,
      "CI_or_error": null,
      "text_access": "abstract_only",
      "n_definition": "mice",
      "scope_region": "whole brain",
      "study_system": "mice, optogenetic fMRI",
      "taxonomic_level": "species (mouse)",
      "scope_population": "large-scale brain networks",
      "value_source_sentence": "it remains unclear how cholinergic and non-cholinergic BF neurons modulate large-scale functional networks",
      "experimental_conditions": "cell-type-specific BF stimulation during fMRI"
    },
    {
      "n": null,
      "doi": "10.1126/science.abb0556",
      "value": "regulate sleep homeostasis via adenosine",
      "method": "optogenetics + adenosine measurement",
      "metric": "BF glutamatergic neuron function",
      "n_analyzed": null,
      "CI_or_error": null,
      "text_access": "abstract_only",
      "n_definition": "mice",
      "scope_region": "basal forebrain and cortex",
      "study_system": "mice",
      "taxonomic_level": "species (mouse)",
      "scope_population": "BF glutamatergic neurons",
      "value_source_sentence": "Sleep and wakefulness are homeostatically regulated by a variety of factors, including adenosine.",
      "experimental_conditions": "glutamatergic BF neuron manipulation"
    },
    {
      "n": null,
      "doi": "10.3389/fncir.2023.1125071",
      "value": "co-release observed in cortically-projecting and hippocampal-projecting BF neurons",
      "method": "gene expression analysis",
      "metric": "ACh-GABA co-release from BF neurons",
      "n_analyzed": null,
      "CI_or_error": null,
      "text_access": "abstract_only",
      "n_definition": "mice, developmental analysis",
      "scope_region": "basal forebrain, medial septum",
      "study_system": "mice",
      "taxonomic_level": "species (mouse)",
      "scope_population": "cholinergic neurons co-expressing GABAergic markers",
      "value_source_sentence": "Acetylcholine and GABA are often co-released, including from VIP-expressing neurons of the cortex, cortically-projecting neurons of the globus pallidus externus and basal forebrain, and hippocampal-projecting neurons of the medial septum.",
      "experimental_conditions": "developmental time series"
    }
  ],
  "comparison_id": "fig_sec4_bf_cell_types_functional",
  "comparison_type": "cross-study functional comparison",
  "homogeneity_check": {
    "caveats": [
      "Different BF cell types targeted (cholinergic vs GABAergic vs glutamatergic)",
      "Different readouts: single-cell transmitter release vs cortical LFP vs whole-brain fMRI",
      "Mixed preparation types: culture vs in vivo",
      "This comparison is intentionally heterogeneous - it maps the functional diversity of BF cell types, not comparable measurements",
      "Figure should be presented as a summary heatmap/schematic, not as quantitative bars"
    ],
    "comparable": false
  },
  "suggested_plot_type": "heatmap"
}

[
  "paper:paper-0a97bc2b6df3",
  "paper:paper-51a312bb1690",
  "paper:paper-751042e17e2a",
  "paper:paper-9fd53bd28bb3",
  "paper:paper-ade9450d3b73"
]

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