Chandelier cell cartridge properties across studies

{
  "papers": [
    {
      "n": 0,
      "doi": "10.1523/jneurosci.4049-12.2013",
      "value": "3-5",
      "method": "immunohistochemistry, confocal microscopy",
      "metric": "Boutons per cartridge",
      "n_analyzed": null,
      "ci_or_error": null,
      "text_access": "fulltext",
      "n_definition": "cartridges analyzed",
      "scope_region": "somatosensory cortex layers 1-2",
      "study_system": "mouse somatosensory cortex",
      "taxonomic_level": "fine type",
      "scope_population": "upper layer chandelier cells",
      "value_source_sentence": "We found that practically all ChC axon terminals contact axon initial segments, with an average of three to five boutons per cartridge.",
      "experimental_conditions": "genetic labeling of upper layer ChCs"
    },
    {
      "n": 20,
      "doi": "10.1016/j.biopsych.2016.09.018",
      "value": "2.7",
      "method": "multilabel immunofluorescence confocal",
      "metric": "Fold change in CB+ cartridge density (schizophrenia vs control)",
      "n_analyzed": "20 matched pairs",
      "ci_or_error": null,
      "text_access": "fulltext",
      "n_definition": "subjects per group",
      "scope_region": "PFC layer 2",
      "study_system": "human prefrontal cortex",
      "taxonomic_level": "fine type",
      "scope_population": "CB+ chandelier cartridges",
      "value_source_sentence": "The mean density of vGAT+/CB+ cartridges was 2.7-fold higher, exclusively in layer 2 of schizophrenia subjects.",
      "experimental_conditions": "postmortem tissue, schizophrenia vs control"
    },
    {
      "n": 0,
      "doi": "10.1002/cne.22792",
      "value": "significantly higher in piriform cortex",
      "method": "immunohistochemistry, quantitative analysis",
      "metric": "Regional comparison: piriform vs neocortex cartridge density",
      "n_analyzed": null,
      "ci_or_error": null,
      "text_access": "fulltext",
      "n_definition": "cartridges counted per region",
      "scope_region": "piriform cortex vs neocortex",
      "study_system": "mouse piriform cortex vs neocortex",
      "taxonomic_level": "fine type",
      "scope_population": "all axo-axonic cartridges",
      "value_source_sentence": "Both the density of axo-axonic cartridges and the degree of gamma-aminobutyric acid membrane transporter 1 innervation in each axo-axonic synapse are significantly higher in the piriform cortex than in the neocortex.",
      "experimental_conditions": "GAT1 immunoreactivity"
    }
  ],
  "comparison_id": "chandelier-cartridge-boutons-per-cartridge",
  "comparison_name": "Chandelier cell cartridge properties across studies",
  "comparison_type": "cross-study conflict",
  "what_it_reveals": "Chandelier cell cartridge density and morphology vary significantly across brain regions and are altered in neuropsychiatric disease, highlighting region-specific organizational principles",
  "homogeneity_check": {
    "caveats": [
      "Entries span mouse and human tissue",
      "Different brain regions (somatosensory cortex, PFC, piriform cortex)",
      "Schizophrenia comparison is human postmortem while others are mouse",
      "Different markers used (GFP genetic vs vGAT/CB immunofluorescence vs GAT1)"
    ],
    "n_definition_uniform": "false",
    "scope_region_uniform": "false",
    "taxonomic_level_uniform": "true",
    "scope_population_uniform": "false"
  },
  "suggested_plot_type": "grouped bar"
}

[
  "paper:paper-0287e42af2f6",
  "paper:paper-03615224c1d6",
  "paper:paper-088fa528776a"
]

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