Version history

{
  "kind": "infographic",
  "prompt": "Chandelier cell cartridge density and morphology vary significantly across brain regions and are altered in neuropsychiatric disease, highlighting region-specific organizational principles",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "n": 0,
        "doi": "10.1523/jneurosci.4049-12.2013",
        "value": "3-5",
        "method": "immunohistochemistry, confocal microscopy",
        "metric": "Boutons per cartridge",
        "n_analyzed": null,
        "ci_or_error": null,
        "text_access": "fulltext",
        "n_definition": "cartridges analyzed",
        "scope_region": "somatosensory cortex layers 1-2",
        "study_system": "mouse somatosensory cortex",
        "taxonomic_level": "fine type",
        "scope_population": "upper layer chandelier cells",
        "value_source_sentence": "We found that practically all ChC axon terminals contact axon initial segments, with an average of three to five boutons per cartridge.",
        "experimental_conditions": "genetic labeling of upper layer ChCs"
      },
      {
        "n": 20,
        "doi": "10.1016/j.biopsych.2016.09.018",
        "value": "2.7",
        "method": "multilabel immunofluorescence confocal",
        "metric": "Fold change in CB+ cartridge density (schizophrenia vs control)",
        "n_analyzed": "20 matched pairs",
        "ci_or_error": null,
        "text_access": "fulltext",
        "n_definition": "subjects per group",
        "scope_region": "PFC layer 2",
        "study_system": "human prefrontal cortex",
        "taxonomic_level": "fine type",
        "scope_population": "CB+ chandelier cartridges",
        "value_source_sentence": "The mean density of vGAT+/CB+ cartridges was 2.7-fold higher, exclusively in layer 2 of schizophrenia subjects.",
        "experimental_conditions": "postmortem tissue, schizophrenia vs control"
      },
      {
        "n": 0,
        "doi": "10.1002/cne.22792",
        "value": "significantly higher in piriform cortex",
        "method": "immunohistochemistry, quantitative analysis",
        "metric": "Regional comparison: piriform vs neocortex cartridge density",
        "n_analyzed": null,
        "ci_or_error": null,
        "text_access": "fulltext",
        "n_definition": "cartridges counted per region",
        "scope_region": "piriform cortex vs neocortex",
        "study_system": "mouse piriform cortex vs neocortex",
        "taxonomic_level": "fine type",
        "scope_population": "all axo-axonic cartridges",
        "value_source_sentence": "Both the density of axo-axonic cartridges and the degree of gamma-aminobutyric acid membrane transporter 1 innervation in each axo-axonic synapse are significantly higher in the piriform cortex than in the neocortex.",
        "experimental_conditions": "GAT1 immunoreactivity"
      }
    ],
    "comparison_id": "chandelier-cartridge-boutons-per-cartridge",
    "comparison_name": "Chandelier cell cartridge properties across studies",
    "comparison_type": "cross-study conflict",
    "what_it_reveals": "Chandelier cell cartridge density and morphology vary significantly across brain regions and are altered in neuropsychiatric disease, highlighting region-specific organizational principles",
    "homogeneity_check": {
      "caveats": [
        "Entries span mouse and human tissue",
        "Different brain regions (somatosensory cortex, PFC, piriform cortex)",
        "Schizophrenia comparison is human postmortem while others are mouse",
        "Different markers used (GFP genetic vs vGAT/CB immunofluorescence vs GAT1)"
      ],
      "n_definition_uniform": "false",
      "scope_region_uniform": "false",
      "taxonomic_level_uniform": "true",
      "scope_population_uniform": "false"
    },
    "suggested_plot_type": "grouped bar"
  },
  "section_id": "section_04_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_04_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewpv-04",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-04",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:paper-0287e42af2f6",
    "paper:paper-03615224c1d6",
    "paper:paper-088fa528776a"
  ],
  "section_title": "Morphological Diversity: Basket Cells, Chandelier Cells, and Beyond",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
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  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_04_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}