{
"papers": [
{
"n": 0,
"doi": "10.1038/s41586-019-0919-7",
"value": "discrete end points corresponding to specific movement directions",
"method": "intracellular + extracellular electrophysiology + perturbation",
"metric": "delay-epoch population geometry in mouse ALM",
"n_analyzed": "not reported in abstract",
"ci_or_error": null,
"text_access": "abstract_only",
"n_definition": "mice",
"scope_region": "ALM",
"study_system": "mouse ALM",
"taxonomic_level": "cortical area",
"scope_population": "all recorded ALM units",
"value_source_sentence": "We show that during the delay epoch, the activity of ALM neurons moved towards discrete end points that correspond to specific movement directions.",
"experimental_conditions": "tactile delayed-response licking"
},
{
"n": 0,
"doi": "10.1038/nature10918",
"value": "choice-specific sequences spanning the trial; cells active at distinct time points",
"method": "two-photon calcium imaging",
"metric": "delay-epoch population geometry in mouse PPC",
"n_analyzed": "not reported in abstract",
"ci_or_error": null,
"text_access": "abstract_only",
"n_definition": "mice",
"scope_region": "PPC",
"study_system": "mouse PPC",
"taxonomic_level": "cortical area",
"scope_population": "all imaged PPC neurons",
"value_source_sentence": "Distinct sequences of neurons were triggered on trials with opposite behavioural choices and defined divergent, choice-specific trajectories through a state space of neuronal population activity.",
"experimental_conditions": "virtual-navigation T-maze decision"
},
{
"n": 0,
"doi": "10.1101/2023.08.04.552026",
"value": "selectivity grows through a sequence of activity-space directions (feedforward-amplification motif)",
"method": "electrophysiology + 2-photon photostimulation",
"metric": "delay-epoch population geometry in mouse ALM",
"n_analyzed": "not reported in abstract",
"ci_or_error": null,
"text_access": "abstract_only",
"n_definition": "mice",
"scope_region": "ALM",
"study_system": "mouse ALM",
"taxonomic_level": "cortical area",
"scope_population": "all recorded ALM units",
"value_source_sentence": "Choice selectivity grew as it flowed through a sequence of directions in activity space.",
"experimental_conditions": "memory-guided directional licking with targeted photostimulation"
},
{
"n": 0,
"doi": "10.1523/JNEUROSCI.3152-17.2018",
"value": "monotonic and low-dimensional",
"method": "high-density silicon-probe electrophysiology",
"metric": "dimensionality of preparatory dynamics in mouse ALM",
"n_analyzed": "not reported in abstract",
"ci_or_error": null,
"text_access": "abstract_only",
"n_definition": "male mice",
"scope_region": "ALM",
"study_system": "mouse ALM",
"taxonomic_level": "cortical area",
"scope_population": "all recorded ALM units",
"value_source_sentence": "Third, delay activity was monotonic and low-dimensional.",
"experimental_conditions": "auditory and tactile delayed-response licking"
}
],
"audit_issues": [
{
"dimension": "scope_region",
"description": "Three rows are ALM and one is PPC. Any apparent disagreement may reflect the regional difference rather than methodological discrepancy.",
"entries_affected": [
"10.1038/s41586-019-0919-7",
"10.1038/nature10918",
"10.1101/2023.08.04.552026",
"10.1523/JNEUROSCI.3152-17.2018"
]
},
{
"dimension": "study_system",
"description": "Recording modality differs (two-photon GCaMP vs. extracellular spikes; some include perturbation, some do not). Task structures differ (tactile delayed-response licking vs. virtual T-maze vs. memory-guided directional licking vs. auditory/tactile delayed-response).",
"entries_affected": [
"10.1038/s41586-019-0919-7",
"10.1038/nature10918",
"10.1101/2023.08.04.552026",
"10.1523/JNEUROSCI.3152-17.2018"
]
},
{
"dimension": "metric_definition",
"description": "'Delay-epoch population geometry' is described as discrete end-points, sequences, monotonic low-dimensional, and feedforward-amplification; these are different geometric descriptors and not commensurable on one axis.",
"entries_affected": [
"10.1038/s41586-019-0919-7",
"10.1038/nature10918",
"10.1101/2023.08.04.552026",
"10.1523/JNEUROSCI.3152-17.2018"
]
}
],
"audit_verdict": "CAVEAT",
"comparison_id": "mouse-association-cortex-delay-coding-geometry",
"comparison_name": "Geometry of mouse association-cortex delay-period activity: stable end points vs. sequences vs. feedforward amplification",
"comparison_type": "cross-study conflict",
"what_it_reveals": "Three competing geometric descriptions of mouse association-cortex delay-period coding — discrete attractor end points, choice-specific sequences, and feedforward-amplified directional propagation — coexist in the literature, with each anchored in a different region/task/recording combination.",
"homogeneity_check": {
"caveats": [
"Region differs (ALM vs. PPC); the apparent disagreement may partly reflect a real regional difference.",
"Recording modality differs (two-photon GCaMP in nature10918 vs. extracellular spikes in s41586-019-0919-7), which biases observable timescales.",
"Task structures differ (tactile delayed-response licking vs. virtual navigation T-maze)."
],
"n_definition_uniform": "true",
"scope_region_uniform": "false",
"taxonomic_level_uniform": "true",
"scope_population_uniform": "true"
},
"suggested_plot_type": "grouped bar",
"mandatory_caption_caveats": [
"Rows span two regions (ALM, PPC) and four task/modality combinations; geometric descriptors are not the same kind of quantity.",
"Two-photon calcium and extracellular spikes have different observable timescales; some rows include perturbation, others do not."
]
}