Version history

{
  "kind": "infographic",
  "prompt": "Three competing geometric descriptions of mouse association-cortex delay-period coding — discrete attractor end points, choice-specific sequences, and feedforward-amplified directional propagation — coexist in the literature, with each anchored in a different region/task/recording combination.",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "n": 0,
        "doi": "10.1038/s41586-019-0919-7",
        "value": "discrete end points corresponding to specific movement directions",
        "method": "intracellular + extracellular electrophysiology + perturbation",
        "metric": "delay-epoch population geometry in mouse ALM",
        "n_analyzed": "not reported in abstract",
        "ci_or_error": null,
        "text_access": "abstract_only",
        "n_definition": "mice",
        "scope_region": "ALM",
        "study_system": "mouse ALM",
        "taxonomic_level": "cortical area",
        "scope_population": "all recorded ALM units",
        "value_source_sentence": "We show that during the delay epoch, the activity of ALM neurons moved towards discrete end points that correspond to specific movement directions.",
        "experimental_conditions": "tactile delayed-response licking"
      },
      {
        "n": 0,
        "doi": "10.1038/nature10918",
        "value": "choice-specific sequences spanning the trial; cells active at distinct time points",
        "method": "two-photon calcium imaging",
        "metric": "delay-epoch population geometry in mouse PPC",
        "n_analyzed": "not reported in abstract",
        "ci_or_error": null,
        "text_access": "abstract_only",
        "n_definition": "mice",
        "scope_region": "PPC",
        "study_system": "mouse PPC",
        "taxonomic_level": "cortical area",
        "scope_population": "all imaged PPC neurons",
        "value_source_sentence": "Distinct sequences of neurons were triggered on trials with opposite behavioural choices and defined divergent, choice-specific trajectories through a state space of neuronal population activity.",
        "experimental_conditions": "virtual-navigation T-maze decision"
      },
      {
        "n": 0,
        "doi": "10.1101/2023.08.04.552026",
        "value": "selectivity grows through a sequence of activity-space directions (feedforward-amplification motif)",
        "method": "electrophysiology + 2-photon photostimulation",
        "metric": "delay-epoch population geometry in mouse ALM",
        "n_analyzed": "not reported in abstract",
        "ci_or_error": null,
        "text_access": "abstract_only",
        "n_definition": "mice",
        "scope_region": "ALM",
        "study_system": "mouse ALM",
        "taxonomic_level": "cortical area",
        "scope_population": "all recorded ALM units",
        "value_source_sentence": "Choice selectivity grew as it flowed through a sequence of directions in activity space.",
        "experimental_conditions": "memory-guided directional licking with targeted photostimulation"
      },
      {
        "n": 0,
        "doi": "10.1523/JNEUROSCI.3152-17.2018",
        "value": "monotonic and low-dimensional",
        "method": "high-density silicon-probe electrophysiology",
        "metric": "dimensionality of preparatory dynamics in mouse ALM",
        "n_analyzed": "not reported in abstract",
        "ci_or_error": null,
        "text_access": "abstract_only",
        "n_definition": "male mice",
        "scope_region": "ALM",
        "study_system": "mouse ALM",
        "taxonomic_level": "cortical area",
        "scope_population": "all recorded ALM units",
        "value_source_sentence": "Third, delay activity was monotonic and low-dimensional.",
        "experimental_conditions": "auditory and tactile delayed-response licking"
      }
    ],
    "audit_issues": [
      {
        "dimension": "scope_region",
        "description": "Three rows are ALM and one is PPC. Any apparent disagreement may reflect the regional difference rather than methodological discrepancy.",
        "entries_affected": [
          "10.1038/s41586-019-0919-7",
          "10.1038/nature10918",
          "10.1101/2023.08.04.552026",
          "10.1523/JNEUROSCI.3152-17.2018"
        ]
      },
      {
        "dimension": "study_system",
        "description": "Recording modality differs (two-photon GCaMP vs. extracellular spikes; some include perturbation, some do not). Task structures differ (tactile delayed-response licking vs. virtual T-maze vs. memory-guided directional licking vs. auditory/tactile delayed-response).",
        "entries_affected": [
          "10.1038/s41586-019-0919-7",
          "10.1038/nature10918",
          "10.1101/2023.08.04.552026",
          "10.1523/JNEUROSCI.3152-17.2018"
        ]
      },
      {
        "dimension": "metric_definition",
        "description": "'Delay-epoch population geometry' is described as discrete end-points, sequences, monotonic low-dimensional, and feedforward-amplification; these are different geometric descriptors and not commensurable on one axis.",
        "entries_affected": [
          "10.1038/s41586-019-0919-7",
          "10.1038/nature10918",
          "10.1101/2023.08.04.552026",
          "10.1523/JNEUROSCI.3152-17.2018"
        ]
      }
    ],
    "audit_verdict": "CAVEAT",
    "comparison_id": "mouse-association-cortex-delay-coding-geometry",
    "comparison_name": "Geometry of mouse association-cortex delay-period activity: stable end points vs. sequences vs. feedforward amplification",
    "comparison_type": "cross-study conflict",
    "what_it_reveals": "Three competing geometric descriptions of mouse association-cortex delay-period coding — discrete attractor end points, choice-specific sequences, and feedforward-amplified directional propagation — coexist in the literature, with each anchored in a different region/task/recording combination.",
    "homogeneity_check": {
      "caveats": [
        "Region differs (ALM vs. PPC); the apparent disagreement may partly reflect a real regional difference.",
        "Recording modality differs (two-photon GCaMP in nature10918 vs. extracellular spikes in s41586-019-0919-7), which biases observable timescales.",
        "Task structures differ (tactile delayed-response licking vs. virtual navigation T-maze)."
      ],
      "n_definition_uniform": "true",
      "scope_region_uniform": "false",
      "taxonomic_level_uniform": "true",
      "scope_population_uniform": "true"
    },
    "suggested_plot_type": "grouped bar",
    "mandatory_caption_caveats": [
      "Rows span two regions (ALM, PPC) and four task/modality combinations; geometric descriptors are not the same kind of quantity.",
      "Two-photon calcium and extracellular spikes have different observable timescales; some rows include perturbation, others do not."
    ]
  },
  "section_id": "section_10",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_10_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewrecurrence-10-persistent-activity",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-10-persistent-activity",
  "source_path": "evidence/section_10_evidence_package.json",
  "source_refs": [
    "paper:67bd565b-2a75-461d-9061-05fb0bb877c2",
    "paper:b1a3a59e-a093-4a17-a122-e55925015edb",
    "paper:e8d68957-7c51-41ac-85bd-f5af67fceba1",
    "paper:paper-8bd2d21e65e2"
  ],
  "section_title": "10. Physiological signature II — persistent activity and attractor dynamics supported by E→E recurrence (delay-period activity in mouse PFC/ALM, working memory, head-direction)",
  "source_policy": {
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    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_10_evidence_package.json",
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