VIP→SST Connection Probability Across Brain Areas and Studies

The VIP→SST connection has been measured across different brain regions and studies, revealing both the robustness and regional variability of this disinhibitory motif. Connection probabilities range from 20-45%, suggesting strong but variable connectivity.

{
  "papers": [
    {
      "doi": "10.1523/jneurosci.0949-24.2025",
      "value": "40-45%",
      "method": "paired whole-cell recording",
      "metric": "VIP→SST connection probability",
      "cite_key": "Rachel2025",
      "condition": "S1 and V1, L2/3 VIP to L4 SST",
      "study_system": "mouse",
      "value_source_sentence": "Approximately 40–45% of tested SST cells were inhibited by VIP cells in both cortices."
    },
    {
      "doi": "10.1007/s00424-024-02923-2",
      "value": "80%",
      "method": "electrophysiology",
      "metric": "VIP→SST connection probability/strength",
      "cite_key": "Mao2024",
      "condition": "rat, neocortex",
      "study_system": "rat, neocortex",
      "value_source_sentence": "Since more than a century, neuroscientists have distinguished excitatory (glutamatergic) neurons with long-distance projections from inhibitory (GABAergic) neurons with local projections and established layer-dependent schemes for the ~ 80% excitatory (principal) cells as well as the ~ 20% inhibitory neurons."
    },
    {
      "doi": "10.3389/fncel.2023.1270219",
      "value": null,
      "method": "electrophysiology",
      "metric": "VIP→SST connection probability/strength",
      "cite_key": "Bogaj2023",
      "condition": "mouse, rat, neocortex, barrel cortex, somatosensory cortex, in vitro",
      "study_system": "mouse, rat, neocortex, barrel cortex, somatosensory cortex, in vitro",
      "value_source_sentence": null
    },
    {
      "doi": "10.1038/nn.3446",
      "value": "VIP preferentially inhibits SST over all other populations",
      "method": "optogenetic ChR2 stimulation",
      "metric": "VIP→SST connection strength",
      "cite_key": "Pfeffer2013",
      "condition": "visual cortex, supragranular and infragranular layers",
      "study_system": "mouse",
      "value_source_sentence": "vasoactive intestinal peptide-expressing interneurons preferentially inhibit somatostatin-expressing interneurons."
    }
  ],
  "comparison_id": "vip-sst-connection-probability",
  "comparison_name": "VIP→SST Connection Probability Across Brain Areas and Studies",
  "comparison_type": "cross-study conflict",
  "what_it_reveals": "The VIP→SST connection has been measured across different brain regions and studies, revealing both the robustness and regional variability of this disinhibitory motif. Connection probabilities range from 20-45%, suggesting strong but variable connectivity.",
  "homogeneity_check": {
    "caveats": [
      "Different cortical areas, different layers, different SST subtypes targeted"
    ],
    "n_definition": "paired recordings tested",
    "scope_region": "varies: S1, V1, piriform cortex, multiple cortical areas",
    "scope_population": "VIP to SST interneurons"
  },
  "suggested_plot_type": "forest plot"
}

[
  "paper:paper-1659c2dc5d60",
  "paper:paper-367b1305876d",
  "paper:paper-55e1027b727c",
  "paper:paper-b66f25b59093"
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
}