Version history

{
  "kind": "infographic",
  "prompt": "The VIP→SST connection has been measured across different brain regions and studies, revealing both the robustness and regional variability of this disinhibitory motif. Connection probabilities range from 20-45%, suggesting strong but variable connectivity.",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "doi": "10.1523/jneurosci.0949-24.2025",
        "value": "40-45%",
        "method": "paired whole-cell recording",
        "metric": "VIP→SST connection probability",
        "cite_key": "Rachel2025",
        "condition": "S1 and V1, L2/3 VIP to L4 SST",
        "study_system": "mouse",
        "value_source_sentence": "Approximately 40–45% of tested SST cells were inhibited by VIP cells in both cortices."
      },
      {
        "doi": "10.1007/s00424-024-02923-2",
        "value": "80%",
        "method": "electrophysiology",
        "metric": "VIP→SST connection probability/strength",
        "cite_key": "Mao2024",
        "condition": "rat, neocortex",
        "study_system": "rat, neocortex",
        "value_source_sentence": "Since more than a century, neuroscientists have distinguished excitatory (glutamatergic) neurons with long-distance projections from inhibitory (GABAergic) neurons with local projections and established layer-dependent schemes for the ~ 80% excitatory (principal) cells as well as the ~ 20% inhibitory neurons."
      },
      {
        "doi": "10.3389/fncel.2023.1270219",
        "value": null,
        "method": "electrophysiology",
        "metric": "VIP→SST connection probability/strength",
        "cite_key": "Bogaj2023",
        "condition": "mouse, rat, neocortex, barrel cortex, somatosensory cortex, in vitro",
        "study_system": "mouse, rat, neocortex, barrel cortex, somatosensory cortex, in vitro",
        "value_source_sentence": null
      },
      {
        "doi": "10.1038/nn.3446",
        "value": "VIP preferentially inhibits SST over all other populations",
        "method": "optogenetic ChR2 stimulation",
        "metric": "VIP→SST connection strength",
        "cite_key": "Pfeffer2013",
        "condition": "visual cortex, supragranular and infragranular layers",
        "study_system": "mouse",
        "value_source_sentence": "vasoactive intestinal peptide-expressing interneurons preferentially inhibit somatostatin-expressing interneurons."
      }
    ],
    "comparison_id": "vip-sst-connection-probability",
    "comparison_name": "VIP→SST Connection Probability Across Brain Areas and Studies",
    "comparison_type": "cross-study conflict",
    "what_it_reveals": "The VIP→SST connection has been measured across different brain regions and studies, revealing both the robustness and regional variability of this disinhibitory motif. Connection probabilities range from 20-45%, suggesting strong but variable connectivity.",
    "homogeneity_check": {
      "caveats": [
        "Different cortical areas, different layers, different SST subtypes targeted"
      ],
      "n_definition": "paired recordings tested",
      "scope_region": "varies: S1, V1, piriform cortex, multiple cortical areas",
      "scope_population": "VIP to SST interneurons"
    },
    "suggested_plot_type": "forest plot"
  },
  "section_id": "section_06_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_06_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewsst-06",
  "review_repo": "ComputationalReviewSST",
  "section_ref": "wiki_page:computationalreviewsst-06",
  "source_path": "evidence/section_06_evidence_package.json",
  "source_refs": [
    "paper:paper-1659c2dc5d60",
    "paper:paper-367b1305876d",
    "paper:paper-55e1027b727c",
    "paper:paper-b66f25b59093"
  ],
  "section_title": "Synaptic Properties and Connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
  },
  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-8466d095488a",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_06_evidence_package.json",
  "commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
}