STDP induction probabilities at mouse barrel-cortex L4→L2/3 synapses with and w…

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    {
      "n": 0,
      "doi": "10.1002/cne.22583",
      "value": "33%",
      "method": "Slice whole-cell paired recording with STDP pairing via L4 stimulation",
      "metric": "Probability of inducing LTP with STDP pairing protocol (undeprived mice)",
      "n_analyzed": "not reported",
      "ci_or_error": null,
      "text_access": "abstract_only",
      "n_definition": "individual L2/3 pyramidal neurons tested with the STDP pairing protocol",
      "scope_region": "Mouse barrel cortex (S1) L4→L2/3 pathway",
      "study_system": "Adolescent mouse barrel cortex L2/3 pyramidal neurons (slice)",
      "taxonomic_level": "fine type",
      "scope_population": "L2/3 pyramidal neurons in normally reared adolescents",
      "value_source_sentence": "The probability of inducing LTP increased from 33% in cortex of undeprived mice to 53% following 7 days of whisker deprivation, and the incidence of LTD with the same protocol decreased from 49% to 9%.",
      "experimental_conditions": "Undeprived"
    }
  ],
  "audit_issues": [
    {
      "dimension": "study_system",
      "description": "All values come from a single source (10.1002/cne.22583). The within-study undeprived vs. deprived contrast is real but does not constitute cross-study replication.",
      "entries_affected": [
        "10.1002/cne.22583"
      ]
    }
  ],
  "audit_verdict": "CAVEAT",
  "comparison_id": "stdp-ltp-ltd-deprivation-barrel",
  "comparison_name": "STDP induction probabilities at mouse barrel-cortex L4→L2/3 synapses with and without whisker deprivation",
  "comparison_type": "dose-response",
  "what_it_reveals": "Sensory deprivation reorganizes the cortical STDP rule: LTP becomes more readily inducible while LTD becomes rarer at the same protocol, indicating experience-dependent metaplasticity at E-E synapses.",
  "homogeneity_check": {
    "caveats": [
      "Two values come from the same study under different deprivation conditions; useful as within-study contrast but does not provide between-lab replication."
    ],
    "n_definition_uniform": "true",
    "scope_region_uniform": "true",
    "taxonomic_level_uniform": "true",
    "scope_population_uniform": "false"
  },
  "suggested_plot_type": "grouped bar",
  "mandatory_caption_caveats": [
    "All values are from a single study; the undeprived vs. deprived contrast is within-experiment, not cross-laboratory replication."
  ]
}

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