Version history

{
  "kind": "infographic",
  "prompt": "Sensory deprivation reorganizes the cortical STDP rule: LTP becomes more readily inducible while LTD becomes rarer at the same protocol, indicating experience-dependent metaplasticity at E-E synapses.",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "n": 0,
        "doi": "10.1002/cne.22583",
        "value": "33%",
        "method": "Slice whole-cell paired recording with STDP pairing via L4 stimulation",
        "metric": "Probability of inducing LTP with STDP pairing protocol (undeprived mice)",
        "n_analyzed": "not reported",
        "ci_or_error": null,
        "text_access": "abstract_only",
        "n_definition": "individual L2/3 pyramidal neurons tested with the STDP pairing protocol",
        "scope_region": "Mouse barrel cortex (S1) L4→L2/3 pathway",
        "study_system": "Adolescent mouse barrel cortex L2/3 pyramidal neurons (slice)",
        "taxonomic_level": "fine type",
        "scope_population": "L2/3 pyramidal neurons in normally reared adolescents",
        "value_source_sentence": "The probability of inducing LTP increased from 33% in cortex of undeprived mice to 53% following 7 days of whisker deprivation, and the incidence of LTD with the same protocol decreased from 49% to 9%.",
        "experimental_conditions": "Undeprived"
      }
    ],
    "audit_issues": [
      {
        "dimension": "study_system",
        "description": "All values come from a single source (10.1002/cne.22583). The within-study undeprived vs. deprived contrast is real but does not constitute cross-study replication.",
        "entries_affected": [
          "10.1002/cne.22583"
        ]
      }
    ],
    "audit_verdict": "CAVEAT",
    "comparison_id": "stdp-ltp-ltd-deprivation-barrel",
    "comparison_name": "STDP induction probabilities at mouse barrel-cortex L4→L2/3 synapses with and without whisker deprivation",
    "comparison_type": "dose-response",
    "what_it_reveals": "Sensory deprivation reorganizes the cortical STDP rule: LTP becomes more readily inducible while LTD becomes rarer at the same protocol, indicating experience-dependent metaplasticity at E-E synapses.",
    "homogeneity_check": {
      "caveats": [
        "Two values come from the same study under different deprivation conditions; useful as within-study contrast but does not provide between-lab replication."
      ],
      "n_definition_uniform": "true",
      "scope_region_uniform": "true",
      "taxonomic_level_uniform": "true",
      "scope_population_uniform": "false"
    },
    "suggested_plot_type": "grouped bar",
    "mandatory_caption_caveats": [
      "All values are from a single study; the undeprived vs. deprived contrast is within-experiment, not cross-laboratory replication."
    ]
  },
  "section_id": "section_12",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_12_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewrecurrence-12-plasticity",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-12-plasticity",
  "source_path": "evidence/section_12_evidence_package.json",
  "source_refs": [
    "paper:paper-f74ca76e5851"
  ],
  "section_title": "12. Plasticity at E→E synapses in mouse — Hebbian, STDP, behavioural-time-scale plasticity; how plasticity shapes the recurrent matrix during learning",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_12_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}