Species Differences and Human Disease figure 1

{
  "axis": {
    "x": "Species / system",
    "y": "Calcium wave speed (µm/s)"
  },
  "notes": "Across both ex vivo tissue and in vivo chimeric paradigms, human astrocytes propagate calcium signals 3–4× faster than rodent astrocytes, suggesting species-intrinsic differences in signaling machinery.",
  "theme": "Human vs rodent astrocyte calcium wave propagation speed",
  "papers": [
    "10.1523/jneurosci.4707-08.2009",
    "10.1016/j.stem.2012.12.015"
  ],
  "datapoints": [
    {
      "doi": "10.1523/jneurosci.4707-08.2009",
      "group": "Human astrocytes (acute surgical neocortex) / Rodent astrocytes (neocortex, estimated from ~4-fold ratio)",
      "units": "µm/s",
      "value": 36,
      "values": {
        "Human astrocytes (acute surgical neocortex)": 36,
        "Rodent astrocytes (neocortex, estimated from ~4-fold ratio)": 9
      },
      "source_sentence": "We report here that protoplasmic astrocytes in human neocortex are 2.6-fold larger in diameter and extend 10-fold more GFAP (glial fibrillary acidic protein)-positive primary processes than their rodent counterparts.",
      "value_source_sentence": "We report here that protoplasmic astrocytes in human neocortex are 2.6-fold larger in diameter and extend 10-fold more GFAP (glial fibrillary acidic protein)-positive primary processes than their rodent counterparts."
    },
    {
      "doi": "10.1016/j.stem.2012.12.015",
      "group": "Engrafted human astrocytes (chimeric mouse) / Host murine astrocytes (chimeric mouse)",
      "units": "µm/s",
      "value": 15.8,
      "values": {
        "Host murine astrocytes (chimeric mouse)": 5.7,
        "Engrafted human astrocytes (chimeric mouse)": 15.8
      },
      "source_sentence": "Line scanning with high temporal resolution (2-4 ms) showed that intracellular Ca 2+ wave propagation was significantly faster in human astrocytes than murine cells; intracellular Ca 2+ increases propagated with a velocity of 15.8 ± 0.7 μm/s among human glia, compared to 5.7 ± 0.4 μm/s in resident murine astrocytes (n=22-34, 6.",
      "value_source_sentence": "Line scanning with high temporal resolution (2-4 ms) showed that intracellular Ca 2+ wave propagation was significantly faster in human astrocytes than murine cells; intracellular Ca 2+ increases propagated with a velocity of 15.8 ± 0.7 μm/s among human glia, compared to 5.7 ± 0.4 μm/s in resident murine astrocytes (n=22-34, 6."
    }
  ],
  "comparison_id": "human_vs_rodent_ca_wave_speed"
}

[
  "paper:paper-76ca66ad8e8e",
  "paper:paper-c0990b7b4903"
]

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  "source_commit_sha": "1a55da0634a3bc04e5688792ed12141ce271d28e",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAstrocytes"
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