Version history

{
  "kind": "infographic",
  "prompt": "Species Differences and Human Disease figure 1",
  "provider": "other",
  "raw_fields": {
    "axis": {
      "x": "Species / system",
      "y": "Calcium wave speed (µm/s)"
    },
    "notes": "Across both ex vivo tissue and in vivo chimeric paradigms, human astrocytes propagate calcium signals 3–4× faster than rodent astrocytes, suggesting species-intrinsic differences in signaling machinery.",
    "theme": "Human vs rodent astrocyte calcium wave propagation speed",
    "papers": [
      "10.1523/jneurosci.4707-08.2009",
      "10.1016/j.stem.2012.12.015"
    ],
    "datapoints": [
      {
        "doi": "10.1523/jneurosci.4707-08.2009",
        "group": "Human astrocytes (acute surgical neocortex) / Rodent astrocytes (neocortex, estimated from ~4-fold ratio)",
        "units": "µm/s",
        "value": 36,
        "values": {
          "Human astrocytes (acute surgical neocortex)": 36,
          "Rodent astrocytes (neocortex, estimated from ~4-fold ratio)": 9
        },
        "source_sentence": "We report here that protoplasmic astrocytes in human neocortex are 2.6-fold larger in diameter and extend 10-fold more GFAP (glial fibrillary acidic protein)-positive primary processes than their rodent counterparts.",
        "value_source_sentence": "We report here that protoplasmic astrocytes in human neocortex are 2.6-fold larger in diameter and extend 10-fold more GFAP (glial fibrillary acidic protein)-positive primary processes than their rodent counterparts."
      },
      {
        "doi": "10.1016/j.stem.2012.12.015",
        "group": "Engrafted human astrocytes (chimeric mouse) / Host murine astrocytes (chimeric mouse)",
        "units": "µm/s",
        "value": 15.8,
        "values": {
          "Host murine astrocytes (chimeric mouse)": 5.7,
          "Engrafted human astrocytes (chimeric mouse)": 15.8
        },
        "source_sentence": "Line scanning with high temporal resolution (2-4 ms) showed that intracellular Ca 2+ wave propagation was significantly faster in human astrocytes than murine cells; intracellular Ca 2+ increases propagated with a velocity of 15.8 ± 0.7 μm/s among human glia, compared to 5.7 ± 0.4 μm/s in resident murine astrocytes (n=22-34, 6.",
        "value_source_sentence": "Line scanning with high temporal resolution (2-4 ms) showed that intracellular Ca 2+ wave propagation was significantly faster in human astrocytes than murine cells; intracellular Ca 2+ increases propagated with a velocity of 15.8 ± 0.7 μm/s among human glia, compared to 5.7 ± 0.4 μm/s in resident murine astrocytes (n=22-34, 6."
      }
    ],
    "comparison_id": "human_vs_rodent_ca_wave_speed"
  },
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  "source_refs": [
    "paper:paper-76ca66ad8e8e",
    "paper:paper-c0990b7b4903"
  ],
  "section_title": "Species Differences and Human Disease",
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      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAstrocytes/blob/1a55da0634a3bc04e5688792ed12141ce271d28e/evidence/section_12_evidence_package.json",
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}