Species Differences and Human Disease figure 2

{
  "axis": {
    "x": "Morphometric parameter",
    "y": "Fold difference relative to rodent"
  },
  "notes": "Human and primate astrocytes are consistently several-fold larger and more complex than those of rodents and other mammals, a conserved hominid-specific feature retained even after xenotransplantation into mouse brain.",
  "theme": "Human vs rodent astrocyte morphological complexity",
  "papers": [
    "10.1523/jneurosci.4707-08.2009",
    "10.1186/s13024-021-00487-8",
    "10.1002/cne.24605"
  ],
  "datapoints": [
    {
      "doi": "10.1523/jneurosci.4707-08.2009",
      "group": "Diameter (human protoplasmic vs rodent) / GFAP+ primary processes (human vs rodent, Oberheim 2009)",
      "units": "fold",
      "value": 2.6,
      "values": {
        "Diameter (human protoplasmic vs rodent)": 2.6,
        "GFAP+ primary processes (human vs rodent, Oberheim 2009)": 10
      },
      "source_sentence": "We report here that protoplasmic astrocytes in human neocortex are 2.6-fold larger in diameter and extend 10-fold more GFAP (glial fibrillary acidic protein)-positive primary processes than their rodent counterparts.",
      "value_source_sentence": "We report here that protoplasmic astrocytes in human neocortex are 2.6-fold larger in diameter and extend 10-fold more GFAP (glial fibrillary acidic protein)-positive primary processes than their rodent counterparts."
    },
    {
      "doi": "10.1186/s13024-021-00487-8",
      "group": "Number of processes (human vs rodent, cited in Leng 2021)",
      "units": "fold",
      "value": 10,
      "values": {
        "Number of processes (human vs rodent, cited in Leng 2021)": 10
      },
      "source_sentence": "Morphologically, human astrocytes are larger and more complex, having around 10 times more processes than their rodent counterparts [ 21 ].",
      "value_source_sentence": "Morphologically, human astrocytes are larger and more complex, having around 10 times more processes than their rodent counterparts [ 21 ]."
    },
    {
      "doi": "10.1002/cne.24605",
      "group": "Primate ILA processes vs marsupial ILA processes / Primate ILA process length vs marsupial ILA process length",
      "units": "fold",
      "value": 4.5,
      "values": {
        "Primate ILA processes vs marsupial ILA processes": 4.5,
        "Primate ILA process length vs marsupial ILA process length": 4.5
      },
      "source_sentence": "We observed the lowest number of processes in marsupials and 4–5 fold more processes and 4–5 times greater length of processes in primates.",
      "value_source_sentence": "We observed the lowest number of processes in marsupials and 4–5 fold more processes and 4–5 times greater length of processes in primates."
    }
  ],
  "comparison_id": "human_vs_rodent_morphometry"
}

[
  "paper:paper-2d9a059ff4a2",
  "paper:paper-4ed3380941f5",
  "paper:paper-76ca66ad8e8e"
]

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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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  "source_commit_sha": "1a55da0634a3bc04e5688792ed12141ce271d28e",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAstrocytes"
}