Version history

{
  "kind": "infographic",
  "prompt": "Species Differences and Human Disease figure 2",
  "provider": "other",
  "raw_fields": {
    "axis": {
      "x": "Morphometric parameter",
      "y": "Fold difference relative to rodent"
    },
    "notes": "Human and primate astrocytes are consistently several-fold larger and more complex than those of rodents and other mammals, a conserved hominid-specific feature retained even after xenotransplantation into mouse brain.",
    "theme": "Human vs rodent astrocyte morphological complexity",
    "papers": [
      "10.1523/jneurosci.4707-08.2009",
      "10.1186/s13024-021-00487-8",
      "10.1002/cne.24605"
    ],
    "datapoints": [
      {
        "doi": "10.1523/jneurosci.4707-08.2009",
        "group": "Diameter (human protoplasmic vs rodent) / GFAP+ primary processes (human vs rodent, Oberheim 2009)",
        "units": "fold",
        "value": 2.6,
        "values": {
          "Diameter (human protoplasmic vs rodent)": 2.6,
          "GFAP+ primary processes (human vs rodent, Oberheim 2009)": 10
        },
        "source_sentence": "We report here that protoplasmic astrocytes in human neocortex are 2.6-fold larger in diameter and extend 10-fold more GFAP (glial fibrillary acidic protein)-positive primary processes than their rodent counterparts.",
        "value_source_sentence": "We report here that protoplasmic astrocytes in human neocortex are 2.6-fold larger in diameter and extend 10-fold more GFAP (glial fibrillary acidic protein)-positive primary processes than their rodent counterparts."
      },
      {
        "doi": "10.1186/s13024-021-00487-8",
        "group": "Number of processes (human vs rodent, cited in Leng 2021)",
        "units": "fold",
        "value": 10,
        "values": {
          "Number of processes (human vs rodent, cited in Leng 2021)": 10
        },
        "source_sentence": "Morphologically, human astrocytes are larger and more complex, having around 10 times more processes than their rodent counterparts [ 21 ].",
        "value_source_sentence": "Morphologically, human astrocytes are larger and more complex, having around 10 times more processes than their rodent counterparts [ 21 ]."
      },
      {
        "doi": "10.1002/cne.24605",
        "group": "Primate ILA processes vs marsupial ILA processes / Primate ILA process length vs marsupial ILA process length",
        "units": "fold",
        "value": 4.5,
        "values": {
          "Primate ILA processes vs marsupial ILA processes": 4.5,
          "Primate ILA process length vs marsupial ILA process length": 4.5
        },
        "source_sentence": "We observed the lowest number of processes in marsupials and 4–5 fold more processes and 4–5 times greater length of processes in primates.",
        "value_source_sentence": "We observed the lowest number of processes in marsupials and 4–5 fold more processes and 4–5 times greater length of processes in primates."
      }
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    "comparison_id": "human_vs_rodent_morphometry"
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    "paper:paper-2d9a059ff4a2",
    "paper:paper-4ed3380941f5",
    "paper:paper-76ca66ad8e8e"
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  "section_title": "Species Differences and Human Disease",
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      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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}