Details

kind
infographic
prompt
Regional variation in IPSC kinetics at PV basket cell synapses provides the biophysical substrate for region-specific oscillation frequencies in hippocampal circuits
provider
other
section_id
section_10_evidence_package
source_url
https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_10_evidence_package.json
target_ref
wiki_page:computationalreviewpv-10
review_repo
ComputationalReviewPV
section_ref
wiki_page:computationalreviewpv-10
source_path
evidence/section_10_evidence_package.json
section_title
Oscillations and Network Dynamics: Gamma, Ripples, and Synchrony
generation_status
complete
review_bundle_ref
analysis_bundle:ab-e6261c8263e7
origin_url
https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_10_evidence_package.json
commit_sha
df9fc7e8d455b084152c9d713558dae0013cef21
created_by
persona-jerome-lecoq-gbo-neuroscience
repository_url
https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (3)
raw_fields
{
  "papers": [
    {
      "n": 0,
      "doi": "10.1073/pnas.192233099",
      "value": "2.5 ms (DG), 1.2 ms (CA3), 1.8 ms (CA1)",
      "method": "patch clamp paired recordings",
      "metric": "IPSC amplitude-weighted decay time constant at BC-BC synapses",
      "n_analyzed": "",
      "ci_or_error": "",
      "text_access": "fulltext",
      "n_definition": "paired recordings from basket cells",
      "scope_region": "hippocampus DG, CA3, CA1",
      "study_system": "PV-EGFP mouse hippocampal slices",
      "taxonomic_level": "fine type",
      "scope_population": "PV basket cells",
      "value_source_sentence": "Unitary inhibitory postsynaptic currents (IPSCs) showed large amplitude and fast time course with mean amplitude-weighted decay time constants of 2.5, 1.2, and 1.8 ms in the dentate gyrus, and the cornu ammonis area 3 (CA3) and 1 (CA1), respectively (33-34°C).",
      "experimental_conditions": "paired recordings at 33-34°C"
    }
  ],
  "comparison_id": "ipsc-kinetics-pv-interneurons",
  "comparison_name": "IPSC decay time constants at PV basket cell synapses across hippocampal subfields",
  "comparison_type": "convergent evidence",
  "what_it_reveals": "Regional variation in IPSC kinetics at PV basket cell synapses provides the biophysical substrate for region-specific oscillation frequencies in hippocampal circuits",
  "homogeneity_check": {
    "caveats": [
      "Single study with within-study regional comparison"
    ],
    "n_definition_uniform": "true",
    "scope_region_uniform": "false",
    "taxonomic_level_uniform": "true",
    "scope_population_uniform": "true"
  },
  "suggested_plot_type": "grouped bar"
}
source_refs
[
  "paper:paper-a9bffd9b9fbb"
]
source_policy
{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}

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