Version history

{
  "kind": "infographic",
  "prompt": "Regional variation in IPSC kinetics at PV basket cell synapses provides the biophysical substrate for region-specific oscillation frequencies in hippocampal circuits",
  "provider": "other",
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      {
        "n": 0,
        "doi": "10.1073/pnas.192233099",
        "value": "2.5 ms (DG), 1.2 ms (CA3), 1.8 ms (CA1)",
        "method": "patch clamp paired recordings",
        "metric": "IPSC amplitude-weighted decay time constant at BC-BC synapses",
        "n_analyzed": "",
        "ci_or_error": "",
        "text_access": "fulltext",
        "n_definition": "paired recordings from basket cells",
        "scope_region": "hippocampus DG, CA3, CA1",
        "study_system": "PV-EGFP mouse hippocampal slices",
        "taxonomic_level": "fine type",
        "scope_population": "PV basket cells",
        "value_source_sentence": "Unitary inhibitory postsynaptic currents (IPSCs) showed large amplitude and fast time course with mean amplitude-weighted decay time constants of 2.5, 1.2, and 1.8 ms in the dentate gyrus, and the cornu ammonis area 3 (CA3) and 1 (CA1), respectively (33-34°C).",
        "experimental_conditions": "paired recordings at 33-34°C"
      }
    ],
    "comparison_id": "ipsc-kinetics-pv-interneurons",
    "comparison_name": "IPSC decay time constants at PV basket cell synapses across hippocampal subfields",
    "comparison_type": "convergent evidence",
    "what_it_reveals": "Regional variation in IPSC kinetics at PV basket cell synapses provides the biophysical substrate for region-specific oscillation frequencies in hippocampal circuits",
    "homogeneity_check": {
      "caveats": [
        "Single study with within-study regional comparison"
      ],
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      "scope_region_uniform": "false",
      "taxonomic_level_uniform": "true",
      "scope_population_uniform": "true"
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  "source_path": "evidence/section_10_evidence_package.json",
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    "paper:paper-a9bffd9b9fbb"
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  "section_title": "Oscillations and Network Dynamics: Gamma, Ripples, and Synchrony",
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      "Local review repositories are read-only inputs.",
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  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_10_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
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}