Details

kind
infographic
prompt
Loss of Rhythmically Bursting Neurons After Cholinergic Lesion
provider
other
section_id
section_04_evidence
source_url
https://github.com/AllenNeuralDynamics/ComputationalReviewNeuromodulation/blob/95db5c630fe54e183d9c452cf826ce502d4a872d/evidence/section_04_evidence.json
target_ref
wiki_page:computationalreviewneuromodulation-04
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ComputationalReviewNeuromodulation
section_ref
wiki_page:computationalreviewneuromodulation-04
source_path
evidence/section_04_evidence.json
section_title
Acetylcholine: Brain-Wide Modulation of Attention, Memory, and Cortical State
generation_status
complete
review_bundle_ref
analysis_bundle:ab-a3dbbaf9b625
origin_url
https://github.com/AllenNeuralDynamics/ComputationalReviewNeuromodulation/blob/95db5c630fe54e183d9c452cf826ce502d4a872d/evidence/section_04_evidence.json
commit_sha
95db5c630fe54e183d9c452cf826ce502d4a872d
created_by
persona-jerome-lecoq-gbo-neuroscience
repository_url
https://github.com/AllenNeuralDynamics/ComputationalReviewNeuromodulation
Raw fields (3)
raw_fields
{
  "title": "Loss of Rhythmically Bursting Neurons After Cholinergic Lesion",
  "papers": [
    {
      "n": null,
      "doi": "10.1152/jn.1998.79.4.1633",
      "value": "41% control vs 17% lesioned",
      "method": "extracellular single unit recording",
      "metric": "percentage of rhythmically bursting septohippocampal neurons",
      "n_analyzed": null,
      "CI_or_error": null,
      "text_access": "abstract_only",
      "n_definition": "septohippocampal neurons recorded in rats",
      "scope_region": "medial septum-diagonal band of Broca",
      "study_system": "rats, urethane-anesthetized and unanesthetized",
      "taxonomic_level": "species (rat)",
      "scope_population": "septohippocampal neurons",
      "value_source_sentence": "The percentage of RB neurons decreased significantly as compared with controls (17 vs. 41% for SHNs and 5 vs. 19% for unidentified septal neurons).",
      "experimental_conditions": "192 IgG-saporin cholinergic lesion vs control"
    }
  ],
  "comparison_id": "fig_sec4_septohippocampal_rb_neurons",
  "comparison_type": "quantitative comparison of cholinergic lesion effects",
  "homogeneity_check": {
    "caveats": [
      "Single study comparison (control vs lesion within same experiment)",
      "Different states examined (urethane-anesthetized vs unanesthetized)",
      "In unanesthetized lesioned rats, no RB septal neurons found during arousal (0% vs 25% in controls)"
    ],
    "comparable": true
  },
  "suggested_plot_type": "bar_with_errorbars"
}
source_refs
[
  "paper:paper-fecc55f0a0e1"
]
source_policy
{
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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95db5c630fe54e183d9c452cf826ce502d4a872d",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewNeuromodulation"
}

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