Neuromodulatory system projection organization: focused vs diffuse

{
  "title": "Neuromodulatory system projection organization: focused vs diffuse",
  "papers": [
    {
      "doi": "10.1162/netn_a_00394",
      "value": "Mouse striatum is ~21.5 mm3 with 1.73 million neurons",
      "n_analyzed": 1730000,
      "n_definition": "total neuron count estimate",
      "scope_region": "striatum",
      "taxonomic_level": "region level",
      "scope_population": "all striatal neurons",
      "value_source_sentence": "The mouse striatum is around 21.5 mm3 with a total of 1.73 million neurons, which correspond to roughly 2.5% of all neurons in the mouse brain"
    },
    {
      "doi": "10.1523/eneuro.0417-21.2023",
      "value": "Approximately 90-95% of striatal neurons are spiny projection neurons (SPNs)",
      "n_analyzed": null,
      "n_definition": "proportion estimate from multiple studies",
      "scope_region": "striatum",
      "taxonomic_level": "cell-type level",
      "scope_population": "striatal neurons",
      "value_source_sentence": "Approximately 90–95% of striatal neurons can be classified as spiny projection neurons (SPNs)"
    }
  ],
  "description": "Comparing projection architecture across the four major neuromodulatory systems — from most focused (DA) to most diffuse (NE) based on axon branching and target specificity data",
  "figure_type": "schematic_comparison",
  "homogeneity_check": "Neuron count estimates and cell-type proportions come from different quantification methods across studies. The 90-95% SPN estimate is well-established but specific proportions vary with region within striatum (dorsal vs ventral)."
}

[
  "paper:paper-a68991ea4c78",
  "paper:paper-a963439b4718"
]

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    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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  "source_commit_sha": "95db5c630fe54e183d9c452cf826ce502d4a872d",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewNeuromodulation"
}