Version history

{
  "kind": "infographic",
  "prompt": "Neuromodulatory system projection organization: focused vs diffuse",
  "provider": "other",
  "raw_fields": {
    "title": "Neuromodulatory system projection organization: focused vs diffuse",
    "papers": [
      {
        "doi": "10.1162/netn_a_00394",
        "value": "Mouse striatum is ~21.5 mm3 with 1.73 million neurons",
        "n_analyzed": 1730000,
        "n_definition": "total neuron count estimate",
        "scope_region": "striatum",
        "taxonomic_level": "region level",
        "scope_population": "all striatal neurons",
        "value_source_sentence": "The mouse striatum is around 21.5 mm3 with a total of 1.73 million neurons, which correspond to roughly 2.5% of all neurons in the mouse brain"
      },
      {
        "doi": "10.1523/eneuro.0417-21.2023",
        "value": "Approximately 90-95% of striatal neurons are spiny projection neurons (SPNs)",
        "n_analyzed": null,
        "n_definition": "proportion estimate from multiple studies",
        "scope_region": "striatum",
        "taxonomic_level": "cell-type level",
        "scope_population": "striatal neurons",
        "value_source_sentence": "Approximately 90–95% of striatal neurons can be classified as spiny projection neurons (SPNs)"
      }
    ],
    "description": "Comparing projection architecture across the four major neuromodulatory systems — from most focused (DA) to most diffuse (NE) based on axon branching and target specificity data",
    "figure_type": "schematic_comparison",
    "homogeneity_check": "Neuron count estimates and cell-type proportions come from different quantification methods across studies. The 90-95% SPN estimate is well-established but specific proportions vary with region within striatum (dorsal vs ventral)."
  },
  "section_id": "section_02_evidence",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewNeuromodulation/blob/95db5c630fe54e183d9c452cf826ce502d4a872d/evidence/section_02_evidence.json",
  "target_ref": "wiki_page:computationalreviewneuromodulation-02",
  "review_repo": "ComputationalReviewNeuromodulation",
  "section_ref": "wiki_page:computationalreviewneuromodulation-02",
  "source_path": "evidence/section_02_evidence.json",
  "source_refs": [
    "paper:paper-a68991ea4c78",
    "paper:paper-a963439b4718"
  ],
  "section_title": "Neuromodulatory Systems: Origins, Projections, and Brain-Wide Architecture",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95db5c630fe54e183d9c452cf826ce502d4a872d",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewNeuromodulation"
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  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-a3dbbaf9b625",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewNeuromodulation/blob/95db5c630fe54e183d9c452cf826ce502d4a872d/evidence/section_02_evidence.json",
  "commit_sha": "95db5c630fe54e183d9c452cf826ce502d4a872d",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewNeuromodulation"
}