SST Neuron Roles in Learning and Plasticity Across Paradigms

{
  "papers": [
    {
      "doi": "10.7554/elife.05558",
      "value": "SST suppression during locomotion enables adult OD plasticity",
      "method": "calcium imaging + intrinsic signal imaging",
      "metric": "Plasticity gating",
      "cite_key": "Fu2015",
      "condition": "V1, ocular dominance plasticity",
      "study_system": "mouse",
      "value_source_sentence": "A cortical disinhibitory circuit for enhancing adult plasticity."
    },
    {
      "doi": "10.1016/j.neuron.2019.01.036",
      "value": "SST neurons enable and maintain learning-dependent sequential patterns",
      "method": "two-photon calcium imaging",
      "metric": "Sequence learning",
      "cite_key": "Adler2019",
      "condition": "cortex, associative learning",
      "study_system": "mouse",
      "value_source_sentence": "Somatostatin-Expressing Interneurons Enable and Maintain Learning-Dependent Sequential Activity Patterns."
    },
    {
      "doi": "10.1038/s41593-018-0330-y",
      "value": "DLS SST neurons track and predict non-freezing epochs during contextual fear recall",
      "method": "in vivo calcium imaging",
      "metric": "Fear learning",
      "cite_key": "Besnard2019",
      "condition": "DLS, contextual fear conditioning",
      "study_system": "mouse",
      "value_source_sentence": "Longitudinal in vivo calcium imaging of DLS SST-INs identified a stable population of footshock responsive SST-INs."
    },
    {
      "doi": "10.1038/nature10674",
      "value": "Disinhibition via SST suppression mediates fear learning in auditory cortex",
      "method": "optogenetics + electrophysiology",
      "metric": "Fear learning",
      "cite_key": "Letzkus2011",
      "condition": "auditory cortex, fear conditioning",
      "study_system": "mouse",
      "value_source_sentence": "A disinhibitory microcircuit for associative fear learning in the auditory cortex."
    }
  ],
  "comparison_id": "sst-learning-plasticity-evidence",
  "comparison_name": "SST Neuron Roles in Learning and Plasticity Across Paradigms",
  "comparison_type": "convergent evidence",
  "what_it_reveals": "SST neurons contribute to multiple forms of learning and plasticity through different mechanisms - disinhibition-gating, sequence maintenance, and fear encoding.",
  "homogeneity_check": {
    "caveats": [
      "Different brain regions (V1, cortex, DLS, A1)",
      "Different learning paradigms (OD plasticity, associative, fear)",
      "SST neurons may play different roles in different forms of learning"
    ],
    "comparable": false
  },
  "suggested_plot_type": "grouped bar"
}

[
  "paper:paper-4126563ac4f2",
  "paper:paper-b0bf857d0018",
  "paper:paper-f22eb24f5525",
  "paper:paper-f87e9546f75c"
]

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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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  "source_commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
}