Version history

{
  "kind": "infographic",
  "prompt": "SST neurons contribute to multiple forms of learning and plasticity through different mechanisms - disinhibition-gating, sequence maintenance, and fear encoding.",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "doi": "10.7554/elife.05558",
        "value": "SST suppression during locomotion enables adult OD plasticity",
        "method": "calcium imaging + intrinsic signal imaging",
        "metric": "Plasticity gating",
        "cite_key": "Fu2015",
        "condition": "V1, ocular dominance plasticity",
        "study_system": "mouse",
        "value_source_sentence": "A cortical disinhibitory circuit for enhancing adult plasticity."
      },
      {
        "doi": "10.1016/j.neuron.2019.01.036",
        "value": "SST neurons enable and maintain learning-dependent sequential patterns",
        "method": "two-photon calcium imaging",
        "metric": "Sequence learning",
        "cite_key": "Adler2019",
        "condition": "cortex, associative learning",
        "study_system": "mouse",
        "value_source_sentence": "Somatostatin-Expressing Interneurons Enable and Maintain Learning-Dependent Sequential Activity Patterns."
      },
      {
        "doi": "10.1038/s41593-018-0330-y",
        "value": "DLS SST neurons track and predict non-freezing epochs during contextual fear recall",
        "method": "in vivo calcium imaging",
        "metric": "Fear learning",
        "cite_key": "Besnard2019",
        "condition": "DLS, contextual fear conditioning",
        "study_system": "mouse",
        "value_source_sentence": "Longitudinal in vivo calcium imaging of DLS SST-INs identified a stable population of footshock responsive SST-INs."
      },
      {
        "doi": "10.1038/nature10674",
        "value": "Disinhibition via SST suppression mediates fear learning in auditory cortex",
        "method": "optogenetics + electrophysiology",
        "metric": "Fear learning",
        "cite_key": "Letzkus2011",
        "condition": "auditory cortex, fear conditioning",
        "study_system": "mouse",
        "value_source_sentence": "A disinhibitory microcircuit for associative fear learning in the auditory cortex."
      }
    ],
    "comparison_id": "sst-learning-plasticity-evidence",
    "comparison_name": "SST Neuron Roles in Learning and Plasticity Across Paradigms",
    "comparison_type": "convergent evidence",
    "what_it_reveals": "SST neurons contribute to multiple forms of learning and plasticity through different mechanisms - disinhibition-gating, sequence maintenance, and fear encoding.",
    "homogeneity_check": {
      "caveats": [
        "Different brain regions (V1, cortex, DLS, A1)",
        "Different learning paradigms (OD plasticity, associative, fear)",
        "SST neurons may play different roles in different forms of learning"
      ],
      "comparable": false
    },
    "suggested_plot_type": "grouped bar"
  },
  "section_id": "section_08_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_08_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewsst-08",
  "review_repo": "ComputationalReviewSST",
  "section_ref": "wiki_page:computationalreviewsst-08",
  "source_path": "evidence/section_08_evidence_package.json",
  "source_refs": [
    "paper:paper-4126563ac4f2",
    "paper:paper-b0bf857d0018",
    "paper:paper-f22eb24f5525",
    "paper:paper-f87e9546f75c"
  ],
  "section_title": "In Vivo Function During Behavior",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
  },
  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-8466d095488a",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_08_evidence_package.json",
  "commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
}