{
"papers": [
{
"n": 0,
"doi": "10.1038/nature17643",
"value": "selectivity recovers within seconds after photoinhibition release",
"method": "electrophysiology + optogenetic silencing",
"metric": "qualitative recovery of selectivity after unilateral ALM silencing during delay",
"n_analyzed": "not reported in abstract",
"ci_or_error": null,
"text_access": "abstract_only",
"n_definition": "mice",
"scope_region": "ALM (premotor cortex)",
"study_system": "mouse ALM",
"taxonomic_level": "cortical area",
"scope_population": "all recorded ALM units",
"value_source_sentence": "We show that preparatory activity is remarkably robust to large-scale unilateral silencing: detailed neural dynamics that drive specific future movements were quickly and selectively restored by the network.",
"experimental_conditions": "unilateral photoinhibition during delay; tactile delayed-response licking"
},
{
"n": 0,
"doi": "10.1016/j.cell.2021.05.026",
"value": "each hemisphere retains persistent activity during perturbations of the other",
"method": "multi-area electrophysiology",
"metric": "persistence of selectivity during perturbation of the opposite hemisphere",
"n_analyzed": "not reported in abstract",
"ci_or_error": null,
"text_access": "abstract_only",
"n_definition": "mice",
"scope_region": "frontal cortex (bilateral)",
"study_system": "mouse frontal cortex (bilateral)",
"taxonomic_level": "cortical area",
"scope_population": "all recorded frontal-cortex units",
"value_source_sentence": "A modular organization was required for the robustness of persistent activity to perturbations: each hemisphere retained persistent activity during perturbations of the other hemisphere, thus preventing local perturbations from spreading.",
"experimental_conditions": "large-scale across-hemisphere recordings with unilateral perturbations"
},
{
"n": 0,
"doi": "10.1038/s41586-019-0919-7",
"value": "end points robust; occasional perturbation switches end point and produces error",
"method": "intracellular + extracellular electrophysiology",
"metric": "robustness of population end points to transient optogenetic perturbation",
"n_analyzed": "not reported in abstract",
"ci_or_error": null,
"text_access": "abstract_only",
"n_definition": "mice",
"scope_region": "ALM (premotor cortex)",
"study_system": "mouse ALM",
"taxonomic_level": "cortical area",
"scope_population": "all recorded ALM units",
"value_source_sentence": "These end points were robust to transient shifts in ALM activity caused by optogenetic perturbations.",
"experimental_conditions": "transient optogenetic perturbations during delay"
}
],
"audit_issues": [
{
"dimension": "scope_region",
"description": "Unilateral ALM (nature17643), bilateral frontal cortex (cell.2021.05.026), and ALM with intracellular + extracellular sampling (s41586-019-0919-7). Region scope is not identical.",
"entries_affected": [
"10.1038/nature17643",
"10.1016/j.cell.2021.05.026",
"10.1038/s41586-019-0919-7"
]
},
{
"dimension": "metric_definition",
"description": "All three rows quote qualitative recovery outcomes from abstracts; no quantitative effect sizes are available with abstract-only access.",
"entries_affected": [
"10.1038/nature17643",
"10.1016/j.cell.2021.05.026",
"10.1038/s41586-019-0919-7"
]
}
],
"audit_verdict": "CAVEAT",
"comparison_id": "delay-photoinhibition-recovery-mouse-frontal",
"comparison_name": "Recovery of mouse frontal-cortex delay-period selectivity after transient unilateral silencing",
"comparison_type": "convergent evidence",
"what_it_reveals": "Three independent studies converge on the conclusion that mouse frontal-cortex preparatory activity is robust to transient perturbations on a seconds timescale, supporting an attractor-like rather than purely feedforward maintenance.",
"homogeneity_check": {
"caveats": [
"Region scope differs: nature17643 is unilateral ALM, cell.2021.05.026 is bilateral frontal cortex, s41586-019-0919-7 is ALM with intracellular + extracellular sampling.",
"All three quote qualitative recovery outcomes from abstracts; quantitative effect sizes were not extracted because they live in figure panels of the body text (text_access=abstract_only)."
],
"n_definition_uniform": "true",
"scope_region_uniform": "false",
"taxonomic_level_uniform": "true",
"scope_population_uniform": "true"
},
"suggested_plot_type": "forest plot",
"mandatory_caption_caveats": [
"Region scope differs (unilateral ALM vs. bilateral frontal cortex vs. ALM with mixed recording modalities).",
"Outcomes are qualitative abstract-level statements, not quantified effect sizes."
]
}