Version history

{
  "kind": "infographic",
  "prompt": "Three independent studies converge on the conclusion that mouse frontal-cortex preparatory activity is robust to transient perturbations on a seconds timescale, supporting an attractor-like rather than purely feedforward maintenance.",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "n": 0,
        "doi": "10.1038/nature17643",
        "value": "selectivity recovers within seconds after photoinhibition release",
        "method": "electrophysiology + optogenetic silencing",
        "metric": "qualitative recovery of selectivity after unilateral ALM silencing during delay",
        "n_analyzed": "not reported in abstract",
        "ci_or_error": null,
        "text_access": "abstract_only",
        "n_definition": "mice",
        "scope_region": "ALM (premotor cortex)",
        "study_system": "mouse ALM",
        "taxonomic_level": "cortical area",
        "scope_population": "all recorded ALM units",
        "value_source_sentence": "We show that preparatory activity is remarkably robust to large-scale unilateral silencing: detailed neural dynamics that drive specific future movements were quickly and selectively restored by the network.",
        "experimental_conditions": "unilateral photoinhibition during delay; tactile delayed-response licking"
      },
      {
        "n": 0,
        "doi": "10.1016/j.cell.2021.05.026",
        "value": "each hemisphere retains persistent activity during perturbations of the other",
        "method": "multi-area electrophysiology",
        "metric": "persistence of selectivity during perturbation of the opposite hemisphere",
        "n_analyzed": "not reported in abstract",
        "ci_or_error": null,
        "text_access": "abstract_only",
        "n_definition": "mice",
        "scope_region": "frontal cortex (bilateral)",
        "study_system": "mouse frontal cortex (bilateral)",
        "taxonomic_level": "cortical area",
        "scope_population": "all recorded frontal-cortex units",
        "value_source_sentence": "A modular organization was required for the robustness of persistent activity to perturbations: each hemisphere retained persistent activity during perturbations of the other hemisphere, thus preventing local perturbations from spreading.",
        "experimental_conditions": "large-scale across-hemisphere recordings with unilateral perturbations"
      },
      {
        "n": 0,
        "doi": "10.1038/s41586-019-0919-7",
        "value": "end points robust; occasional perturbation switches end point and produces error",
        "method": "intracellular + extracellular electrophysiology",
        "metric": "robustness of population end points to transient optogenetic perturbation",
        "n_analyzed": "not reported in abstract",
        "ci_or_error": null,
        "text_access": "abstract_only",
        "n_definition": "mice",
        "scope_region": "ALM (premotor cortex)",
        "study_system": "mouse ALM",
        "taxonomic_level": "cortical area",
        "scope_population": "all recorded ALM units",
        "value_source_sentence": "These end points were robust to transient shifts in ALM activity caused by optogenetic perturbations.",
        "experimental_conditions": "transient optogenetic perturbations during delay"
      }
    ],
    "audit_issues": [
      {
        "dimension": "scope_region",
        "description": "Unilateral ALM (nature17643), bilateral frontal cortex (cell.2021.05.026), and ALM with intracellular + extracellular sampling (s41586-019-0919-7). Region scope is not identical.",
        "entries_affected": [
          "10.1038/nature17643",
          "10.1016/j.cell.2021.05.026",
          "10.1038/s41586-019-0919-7"
        ]
      },
      {
        "dimension": "metric_definition",
        "description": "All three rows quote qualitative recovery outcomes from abstracts; no quantitative effect sizes are available with abstract-only access.",
        "entries_affected": [
          "10.1038/nature17643",
          "10.1016/j.cell.2021.05.026",
          "10.1038/s41586-019-0919-7"
        ]
      }
    ],
    "audit_verdict": "CAVEAT",
    "comparison_id": "delay-photoinhibition-recovery-mouse-frontal",
    "comparison_name": "Recovery of mouse frontal-cortex delay-period selectivity after transient unilateral silencing",
    "comparison_type": "convergent evidence",
    "what_it_reveals": "Three independent studies converge on the conclusion that mouse frontal-cortex preparatory activity is robust to transient perturbations on a seconds timescale, supporting an attractor-like rather than purely feedforward maintenance.",
    "homogeneity_check": {
      "caveats": [
        "Region scope differs: nature17643 is unilateral ALM, cell.2021.05.026 is bilateral frontal cortex, s41586-019-0919-7 is ALM with intracellular + extracellular sampling.",
        "All three quote qualitative recovery outcomes from abstracts; quantitative effect sizes were not extracted because they live in figure panels of the body text (text_access=abstract_only)."
      ],
      "n_definition_uniform": "true",
      "scope_region_uniform": "false",
      "taxonomic_level_uniform": "true",
      "scope_population_uniform": "true"
    },
    "suggested_plot_type": "forest plot",
    "mandatory_caption_caveats": [
      "Region scope differs (unilateral ALM vs. bilateral frontal cortex vs. ALM with mixed recording modalities).",
      "Outcomes are qualitative abstract-level statements, not quantified effect sizes."
    ]
  },
  "section_id": "section_10",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_10_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewrecurrence-10-persistent-activity",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-10-persistent-activity",
  "source_path": "evidence/section_10_evidence_package.json",
  "source_refs": [
    "paper:paper-3b6e7b0cf19b",
    "paper:67bd565b-2a75-461d-9061-05fb0bb877c2",
    "paper:e5455d9e-9c3e-450b-bddf-f40f62ee661b"
  ],
  "section_title": "10. Physiological signature II — persistent activity and attractor dynamics supported by E→E recurrence (delay-period activity in mouse PFC/ALM, working memory, head-direction)",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
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  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_10_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}