Quantitative E→E recurrent connectivity strength in mouse V1 L2/3

{
  "title": "Quantitative E→E recurrent connectivity strength in mouse V1 L2/3",
  "values": [
    {
      "study": "Cossell 2015 (mouse V1 L2/3 paired patch)",
      "source_doi": "10.1038/nature14182",
      "mean_EPSP_mV": 0.45,
      "median_EPSP_mV": 0.19,
      "mean_EPSP_sd_mV": 0.68
    },
    {
      "study": "Ko 2011 (mouse V1 L2/3 paired patch)",
      "source_doi": "10.1038/nature09880",
      "matched_orientation_connection_rate_vs_orthogonal": 2
    },
    {
      "study": "Lefort 2009 (mouse barrel C2 column)",
      "source_doi": "10.1016/j.neuron.2008.12.020",
      "characterization": "strongest excitatory influence from L4 presynaptic; rare large-amplitude connections"
    }
  ],
  "variable_x": "study",
  "variable_y": "EPSP amplitude and feature-specific connection probability",
  "audit_issues": [
    {
      "dimension": "metric_definition",
      "description": "Row 1 reports median and mean EPSP amplitude (mV); row 2 reports a connection-probability ratio (matched-orientation ÷ orthogonal); row 3 reports a qualitative characterization of the S1 barrel column. Three different statistics on the y-axis.",
      "entries_affected": [
        "10.1038/nature14182",
        "10.1038/nature09880",
        "10.1016/j.neuron.2008.12.020"
      ]
    },
    {
      "dimension": "scope_region",
      "description": "Rows 1–2 are mouse V1 L2/3; row 3 is mouse S1 barrel C2 column. Region label 'mouse V1 L2/3' in the title does not cover row 3.",
      "entries_affected": [
        "10.1016/j.neuron.2008.12.020"
      ]
    }
  ],
  "audit_verdict": "CAVEAT",
  "interpretation": "Mouse V1 L2/3 E→E connectivity is heavy-tailed (median 0.19 mV, mean 0.45 mV; SD/mean ≈ 1.5) with strong feature specificity (matched orientations connect at 2× the rate of orthogonal pairs) — quantitatively consistent with the strongly-coupled, feature-specific subnetwork structure required by balanced-amplification and SSN theories.",
  "data_source_doi": "10.1038/nature14182",
  "mandatory_caption_caveats": [
    "Y-axis pools EPSP amplitude (mV) and a connection-probability ratio — two different quantities. Either separate or state the y-axis as 'study-specific summary statistic.'",
    "Title says 'mouse V1 L2/3' but row 3 is mouse S1 barrel cortex."
  ]
}

[]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}