Version history

{
  "kind": "infographic",
  "prompt": "Quantitative E→E recurrent connectivity strength in mouse V1 L2/3",
  "provider": "other",
  "raw_fields": {
    "title": "Quantitative E→E recurrent connectivity strength in mouse V1 L2/3",
    "values": [
      {
        "study": "Cossell 2015 (mouse V1 L2/3 paired patch)",
        "source_doi": "10.1038/nature14182",
        "mean_EPSP_mV": 0.45,
        "median_EPSP_mV": 0.19,
        "mean_EPSP_sd_mV": 0.68
      },
      {
        "study": "Ko 2011 (mouse V1 L2/3 paired patch)",
        "source_doi": "10.1038/nature09880",
        "matched_orientation_connection_rate_vs_orthogonal": 2
      },
      {
        "study": "Lefort 2009 (mouse barrel C2 column)",
        "source_doi": "10.1016/j.neuron.2008.12.020",
        "characterization": "strongest excitatory influence from L4 presynaptic; rare large-amplitude connections"
      }
    ],
    "variable_x": "study",
    "variable_y": "EPSP amplitude and feature-specific connection probability",
    "audit_issues": [
      {
        "dimension": "metric_definition",
        "description": "Row 1 reports median and mean EPSP amplitude (mV); row 2 reports a connection-probability ratio (matched-orientation ÷ orthogonal); row 3 reports a qualitative characterization of the S1 barrel column. Three different statistics on the y-axis.",
        "entries_affected": [
          "10.1038/nature14182",
          "10.1038/nature09880",
          "10.1016/j.neuron.2008.12.020"
        ]
      },
      {
        "dimension": "scope_region",
        "description": "Rows 1–2 are mouse V1 L2/3; row 3 is mouse S1 barrel C2 column. Region label 'mouse V1 L2/3' in the title does not cover row 3.",
        "entries_affected": [
          "10.1016/j.neuron.2008.12.020"
        ]
      }
    ],
    "audit_verdict": "CAVEAT",
    "interpretation": "Mouse V1 L2/3 E→E connectivity is heavy-tailed (median 0.19 mV, mean 0.45 mV; SD/mean ≈ 1.5) with strong feature specificity (matched orientations connect at 2× the rate of orthogonal pairs) — quantitatively consistent with the strongly-coupled, feature-specific subnetwork structure required by balanced-amplification and SSN theories.",
    "data_source_doi": "10.1038/nature14182",
    "mandatory_caption_caveats": [
      "Y-axis pools EPSP amplitude (mV) and a connection-probability ratio — two different quantities. Either separate or state the y-axis as 'study-specific summary statistic.'",
      "Title says 'mouse V1 L2/3' but row 3 is mouse S1 barrel cortex."
    ]
  },
  "section_id": "section_09",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewrecurrence-09-amplification-isn",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-09-amplification-isn",
  "source_path": "evidence/section_09_evidence_package.json",
  "source_refs": [],
  "section_title": "9. Physiological signature I — recurrent amplification of weak inputs in mouse cortex; balanced-amplification regimes; ISN operation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
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  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}